Chest
Volume 141, Issue 4, April 2012, Page 1125
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Correspondence
Important Antiretroviral Drug Interactions With Benzodiazepines Used for Sedation During Bronchoscopy

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To the Editor

We read with interest the article by Wahidi et al1 in CHEST (November 2011). We are concerned that the section on midazolam did not provide up-to-date information on interactions between this drug and highly active antiretroviral therapy (ART) used in HIV-infected individuals.

The study that is quoted in the consensus statement suggests that higher doses of midazolam may be needed in certain HIV-infected populations.2 We believe this reflects the situation in IV-drug users who are HIV-positive

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Financial/nonfinancial disclosures: The authors have reported to CHEST the following conflicts of interest: Mr Marshall has received honoraria for speaker fees, conference registration, and travel expenses from Janssen, Bristol-Myers Squibb, ViiV Healthcare, Abbott, Gilead Science, and Merck Sharp & Dohme. Drs José and Lipman have reported that no potential conflicts of interest exist with any companies/organizations whose products or services may be discussed in this article.

Reproduction of this article is prohibited without written permission from the American College of Chest Physicians (http://www.chestpubs.org/site/misc/reprints.xhtml).

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