Chest
Clinical InvestigationsPrimary Pulmonary Lymphomas: A Clinical Study of 70 Cases in Nonimmunocompromised Patients
Section snippets
METHODS
French respiratory physicians were asked to participate in the Clinicopathological Research Group under the auspices of the Société de Pneumologie de Langue Française by referring standardized detailed clinical information, x-ray films, tomograms and computed tomography (CT) scans on nonimmunocompromised patients whose condition they diagnosed between 1970 and 1990 as primary pulmonary non-Hodgkins lymphoma or “pseudolymphoma.” In addition, they were asked to refer cases in which pulmonary
Study Population
Seventy patients were included in the study. Thirty other referred cases were rejected on the basis of the following: histopathologic findings, 13 cases (pathologic diagnosis other than lymphoma in 7, size or quality or both of specimens insufficient for confident diagnosis of lymphoma in 6) and clinical findings, 17 cases (extrathoracic lymphoma present in 7, predominant mediastinal lymphomatous lesions in 5, incomplete clinical information in 5).
Furthermore, six other cases were referred (not
DISCUSSION
The frequency of lymphomas arising in the lung is estimated to be less than 1 percent of all lymphomas.10 The strict inclusion criteria we chose for considering a lymphoma as primary in the lung probably exclude pulmonary localizations of lymphomas of another origin, and this confers a reliable homogeneity to this series.
Eighty-seven percent of our patients had a LG lymphoma and 13 percent had a HG lymphoma. This predominance of LG lymphomas is found in all previously reported series.3, 8, 9, 10
ACKNOWLEDGMENT
We thank T. Greenland for reviewing the translation of this paper and M. C. Thévenet for secretarial assistance throughout the study and preparation of the manuscript. The following clinicians (all from France) also participated in the study on primary pulmonary lymphomas performed by the Clinicopathologic Research Group by contributing one or more patients: J. Y. Bayle (Lyon); J. P. Bernard (Lyon); J. P Bonniot (Chevilly Larue); J. M. Bréchot (Paris); J. Cadranel (Paris); B. Coiffier (Lyon);
REFERENCES (24)
- et al.
Primary malignant lymphoma of the lung: histopathologic and immunologic evaluation of nine cases
Hum Pathol
(1984) - et al.
Detection of pulmonary lymphoma by bronchoalveolar lavage
Chest
(1987) - et al.
Confirmation of lymphomatous pulmonary involvement by immunophenotypic and gene rearrangement analysis of bronchoalveolar lavage fluid
Mayo Clin Proc
(1990) - et al.
Small lymphocytic pulmonary lymphoma: diagnosis by transthoracic fine needle aspiration
Chest
(1989) - et al.
Primary non-Hodgkin's lymphoma and pseudolymphoma of lung: a study of 161 patients
Hum Pathol
(1983) - et al.
Lymphoproliferative disorders of the thorax
Semin Roentgenol
(1975) - et al.
Endobronchial non-Hodgkin's lymphoma
Chest
(1983) - et al.
Primary pulmonary lymphoma: a re-appraisal of its histogenesis and its relationship to pseudolymphoma and lymphoid interstitial pneumonia
Histopathology
(1988) - et al.
Primary lymphomas of the lung: morphological, immunohistochemical and clinical features
Histopathology
(1990) - et al.
Pulmonary processes of mature-appearing lymphocytes: pseudolymphomas, well-differentiated lymphocytic lymphomas, and lymphocytic interstitial pneumonitis
Radiology
(1978)
Pulmonary lymphomas and other pulmonary lymphoid lesions: a clinicopathologic and immunologic study of 64 patients
Cancer
Primary pulmonary lymphomas: a clinicopathologic analysis of 36 cases
Cancer
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This work was supported by grant CNEP 90CN43 from Institut National de la Santé et de la Recherche Médicale, Paris, France
Manuscript received February 4; revision accepted May 28.