Chest
Clinical InvestigationsBronchogenic Carcinoma in Patients with Pulmonary Histiocytosis X
Section snippets
Patients with Bronchogenic Carcinoma (Table 1)
The mean age of our patients at the time of diagnosis of Hx was 42 years. Histiocytosis X was diagnosed either by open lung biopsy (four cases) or bone biopsy (one case). The chest roentgenogram was always abnormal, showing various associations of reticulation, cysts, and nodules, according to the classification of Basset et al.3 Bronchogenic carcinoma occurred 10.5 years on the average (range, 5 to 20 years) after the discovery of Hx. The type of carcinoma varied: squamous cell (patients 1 and
Discussion
Among the 93 cases of pulmonary Hx diagnosed, we observed the development of lung carcinoma in five patients after a mean Hx duration of 10.5 years. The annual bronchogenic carcinoma risk of 1,040/ 100,000 appears exceptionally high, lending support to the notion that patients with pulmonary Hx have a high risk of developing lung carcinoma. Moreover, since many of our patients were younger than 40 years old at the time of the last consultation, the observed rate of bronchogenic carcinoma
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Manuscript received October 17, 1990; revision accepted September 16, 1991.