Chest
Original ResearchCystic FibrosisEffects of Exercise on Respiratory Flow and Sputum Properties in Patients With Cystic Fibrosis
Section snippets
Subjects
Adults with CF were recruited from the CF Clinic at Royal Prince Alfred Hospital in Sydney, New South Wales, Australia. Subjects were excluded if they had received a lung transplantation, were infected with Burkholderia cepacia complex, or were not clinically stable. Research procedures were approved by the Sydney South West Area Health Service Ethics Committee (Protocol X-05-0020), and subjects provided written informed consent prior to participation.
Study Design
Subjects participated in a 3-day crossover
Results
Fifteen subjects with CF were recruited, and 14 completed the study. Participant baseline characteristics are presented in Table 1, Table 2. One participant withdrew after the first visit because of a respiratory exacerbation. Results for this subject on the first day were similar to those of the other 14 but have not been included in the analyses because of the crossover design of the study.
There were no significant differences in preintervention ease of expectoration or sputum properties on
Discussion
The primary purpose of this study was to determine the effects of treadmill and cycle exercise on mechanisms of mucus clearance in CF. To our knowledge, this study is the first to examine the in vivo changes in sputum properties and airflow bias (PEF:PIF) with exercise in CF. The main finding was the reduction in sputum mechanical impedance with treadmill exercise compared with control.
Ventilation and respiratory flow were higher during treadmill and cycle exercise compared with control. The
Acknowledgments
Author contributions: Dr Dwyer: contributed to the study design, data collection, measurement and analysis of sputum properties, interpretation of the findings, and writing of the manuscript.
Dr Alison: contributed to the study design, interpretation of the findings, and writing of the manuscript.
Dr McKeough: contributed to the study design, data collection, interpretation of the findings, and writing of the manuscript.
Dr Daviskas: contributed to the study design, measurement and analysis of
References (39)
- et al.
Evidence for periciliary liquid layer depletion, not abnormal ion composition, in the pathogenesis of cystic fibrosis airways disease
Cell
(1998) - et al.
Effect of swimming on forced expiration and sputum clearance in cystic fibrosis
Lancet
(1981) - et al.
Effect of addition of exercise to chest physiotherapy on sputum expectoration and lung function in adults with cystic fibrosis
Respir Med
(1994) - et al.
The relationship between flow transients and bronchial lability in cystic fibrosis
Chest
(1981) - et al.
Sputum rheology changes in cystic fibrosis lung disease following two different types of physiotherapy: flutter vs autogenic drainage
Chest
(1998) Generation and attenuation of transient impulsive forces beneath the foot: a review
Gait Posture
(1999)- et al.
Inhaled mannitol improves the hydration and surface properties of sputum in patients with cystic fibrosis
Chest
(2010) - et al.
The effects of postural drainage and positive expiratory pressure physiotherapy on tracheobronchial clearance in cystic fibrosis
Chest
(1991) - et al.
The mechanism of exercise-induced asthma is
J Allergy Clin Immunol
(2000) - et al.
Role of mechanical stress in regulating airway surface hydration and mucus clearance rates
Respir Physiol Neurobiol
(2008)
Mucociliary clearance in cystic fibrosis
Pediatr Pulmonol
Physiotherapy management of cystic fibrosis
Chron Respir Dis
Chest physical therapy management of patients with cystic fibrosis. A meta-analysis
Am J Respir Crit Care Med
Physical training for cystic fibrosis
Cochrane Database Syst Rev
Changes in airflow obstruction and oxygen saturation in response to exercise and bronchodilators in cystic fibrosis
Pediatr Pulmonol
Exercise performance and rehabilitation in cystic fibrosis
Crit Rev Phys Rehabil Med
Mucus clearance by two-phase gas-liquid flow mechanism: asymmetric periodic flow model
J Appl Physiol
Cough
Exercise inhibits epithelial sodium channels in patients with cystic fibrosis
Am J Respir Crit Care Med
Cited by (0)
Reproduction of this article is prohibited without written permission from the American College of Chest Physicians (http://www.chestpubs.org/site/misc/reprints.xhtml).
Funding/Support: Dr Dwyer was supported by an Australian Postgraduate Award scholarship from the University of Sydney. No other funding was received for this work.