Chest
Original ResearchInterventional PulmonologyTransbronchial and Transesophageal Fine-Needle Aspiration Using an Ultrasound Bronchoscope in Mediastinal Staging of Potentially Operable Lung Cancer
Section snippets
Patients
We prospectively enrolled consecutive patients with histologically confirmed or strongly suspected potentially operable NSCLC who visited the Center for Lung Cancer of the National Cancer Center in Goyang Korea from August 2008 to March 2009. After staging workup for NSCLC, including CT scans of the chest and upper abdomen, integrated PET-CT scans, and brain MRI (and/or bone scans), we excluded patients who had M1 disease and inoperable T4 disease based on the international system for staging
Endobronchial Ultrasound-Guided Transbronchial Needle Aspiration
During the study period, we screened 685 patients with proven or suspected lung cancer. One hundred fifty patients who met the inclusion criteria were enrolled in the study. The characteristics and the clinical courses of the patients are presented in Table 1 and Figure 1, respectively. EBUS was performed on all participants, and EBUS-TBNA was performed on 310 lesions (299 mediastinal nodal stations, 8 N1 nodal stations, and three lung masses). The characteristics of the EBUS-TBNA procedure are
Discussion
To our knowledge, this study is the first prospective investigation demonstrating the usefulness of combining transbronchial and transesophageal fine needle aspiration using an ultrasound bronchoscope in the mediastinal staging of lung cancer. We performed EUS-B-FNA safely, and only one complication was observed after EBUS-TBNA. We observed 6.7% of additional diagnostic gain in detecting mediastinal metastasis by adding EUS-B-FNA to EBUS-TBNA. Although the difference in diagnostic gain did not
Acknowledgments
Author contributions: Dr Hwangbo: contributed to study conception and design, provision of study materials or patients, collection and assembly of data, data analysis and interpretation, manuscript writing, and final approval of the manuscript.
Dr G.-K. Lee: contributed to data analysis and interpretation and final approval of the manuscript.
Dr Hee S. Lee: contributed to provision of study materials or patients and final approval of the manuscript.
Dr Lim: contributed to data analysis and
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Funding/Support: This work was supported by the National Cancer Center [Grant 710620].
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