Chest
Original ResearchLung Function TestingApplication of a Shortened Inhaled Adenosine-5′-Monophosphate Challenge in Young Children Using the Forced Oscillation Technique
Section snippets
Subjects
Forty-one children (25 boys; age range, 3.5 to 7.5 years) underwent paired inhaled AMP challenges. Nine children had a history of respiratory symptoms (parent-reported wheeze, asthma, or persistent cough without colds, but not in the past 12 months), 30 children had current wheeze (parent-reported wheeze, asthma, or persistent cough without colds in the past 12 months), and 2 children had no history of respiratory symptoms. Children were asymptomatic on the day of the test and had no history of
Results
Eighteen children completed both a shortened and a standard inhaled AMP challenge. The mean time elapsed between tests was 16 ± 11.4 days (range, 7 to 42 days). Three children undertaking protocol 1 did not complete the standard (nine-step) challenge and were excluded from further analysis. Reasons for noncompletion were exacerbation of symptoms in the period preceding the AMP challenge (n = 1) or premature termination of the challenge arising from poor subject cooperation (n = 2).
All children
Discussion
The present study has demonstrated that the combined use of FOT and shortened AMP challenge is feasible in young children. Importantly, we demonstrated a high degree of concordance in responsiveness between a shortened challenge and the standard AMP protocol. Further, we demonstrated that the shortened challenge was repeatable for determining BHR to AMP. Interestingly, the majority of children responded with an increase in Rrs8 either alone (> 47%) or in combination with audible wheeze (> 33%),
Acknowledgment
The authors would like to acknowledge the assistance of Dr. K. Udomittipong for her assistance in performing the AMP challenge tests.
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This study was funded by the Asthma Foundation of Western Australia.
The authors have reported to the ACCP that no significant conflicts of interest exist with any companies/organizations whose products or services may be discussed in this article.
Reproduction of this article is prohibited without written permission from the American College of Chest Physicians (www.chestjournal.org/site/misc/reprints.xhtml).