Chest
ORIGINAL RESEARCHSLEEP MEDICINESleep-Disordered Breathing and Uric Acid in Overweight and Obese Children and Adolescents
Section snippets
Patient Characteristics
We recruited children and adolescents who were 6 to 17 years of age who presented as overweight or obese between January 2001 and June 2006 at the Pediatric Obesity Clinic of the Antwerp University Hospital. Children were not included when they had any chronic medical condition, or any genetic, neuromuscular or craniofacial syndromes. Patients were classified as prepubertal or pubertal.4 All subjects underwent all measurements as part of their routine clinical evaluation. This case study was
Patient and Polysomnographic Characteristics
A total of 94 children and adolescents were initially included in the study; afterward, 1 subject was excluded because of an abnormal serum creatinine value of 1.5 mg/dL. Of those subjects, 44% were boys, 58% were prepubertal (mean age, 11.1 ± 2.5 years; age range, 6.3 to 16.3 years). The mean BMI z-score was 2.31 ± 0.50 (range, 1.32 to 3.83); and 25 subjects (27%) were classified as overweight, and 68 subjects (73%) as obese. All subjects were nondiabetic.
All children had a normal UA excretion
Discussion
This is the first study to assess the influence of SDB on UA metabolism in overweight children and adolescents. This study demonstrates is that the severity of sleep apnea was associated with higher serum UA levels after controlling for gender, puberty, and adiposity.
UA metabolism and renal handling in children differ from those in adults. From childhood to adolescence, a child's serum UA level increases linearly; the urinary UA/creatinine ratio is higher in young children and declines to adult
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The authors have reported to the ACCP that no significant conflicts of interest exist with any companies/organizations whose products or services may be discussed in this article.