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Original ResearchPulmonary HypertensionRegistry and Survival Study in Chinese Patients With Idiopathic and Familial Pulmonary Arterial Hypertension
Section snippets
Patients
This registry study was conducted at Fu Wai Hospital, Chinese Academy of Medical Sciences, and Peking Union Medical College from January 1999 to October 2004. A total of 72 consecutive patients in whom idiopathic and familial PAH had been diagnosed were enrolled into this study. Patients with suspected pulmonary hypertension were admitted to a hospital ward for further evaluation. PAH was defined as a mean PAP of > 25 mm Hg at rest by right heart catheterization (RHC)6 or systolic PAP exceeding
Demographic Characteristics and Comparison With NIH Registry and French Registry
Of the 72 patients enrolled in this study, 21 were men and 51 were women (Table 1). The female patient/male patient ratio was 2.4:1. The mean age was 35.9 ± 12.2 years (range, 9.7 to 73.8 years). According to different genders, there was no difference in patients' age when they received the first medical examination (p = 0.36). Of these 72 patients, 11.1% (8 patients) were < 20 years old, 56.9% (41 patients) were 20 to 39 years old, 27.8% (20 patients) were 40 to 59 years old, and 4.2% (3
Discussion
The present study is the first report from China on data concerning idiopathic and familial PAH. Dyspnea on exertion is the most common symptom of disease onset, occurring in 98.6% of Chinese patients with idiopathic and familial PAH, predominantly in women (women/men ratio, 2.4:1); idiopathic and familial PAH can occur at any age but most often occurred between the ages of 20 and 59 years. The survival rate decreased dramatically after 5 years. These results were similar to those in the report
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Cited by (0)
This study was supported by research grant No. 2002BA711A08 (“National Key Technologies R&D Program”) from the National Ministry of Science and Technology, People's Republic of China.
The authors have reported to the ACCP that no significant conflicts of interest exist with any companies/organizations whose products or services may be discussed in this article.
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These authors contributed equally to the work.