Environmental and Ooccupational DisordersSpecific immunotherapy with a standardized latex extract in allergic workers: A double-blind, placebo-controlled study☆
Section snippets
Study design
This clinical trial was conducted in accordance with good clinical practice after approval by the hospital ethics committee and the Spanish Medicine Agency. All patients provided written consent to participate in the trial. This was a randomized, double-blind, placebo-controlled trial conducted in parallel groups. Fifty patients were screened, and 24 were randomized into 2 treatment groups (ie, active or placebo groups). Treatment lasted 6 months, and tolerance to SIT was monitored throughout
Results
The baseline characteristics of subjects are shown in Table I. Both treatment groups were similar in their demographic and clinical characteristics at baseline.
Discussion
This study compares the results of latex SIT with placebo in sensitized workers in terms of safety and efficacy end points. To our knowledge, this is the second double-blind, placebo-controlled study published on latex SIT. The first was carried out by Leynadier et al9 at the end of 2000. In this trial a similar crude extract of latex was used for SIT. These authors used a maximum dose of 5 to 10 reactivity units, which corresponds to 1 to 2 μg of total protein, in contrast to the maximum dose
References (20)
- et al.
Prospective study of risk factors in natural rubber latex hypersensitivity
J Allergy Clin Immunol
(1993) - et al.
Prevalence of latex allergy in operating room nurses
J Allergy Clin lmmunol
(1992) - et al.
Prevalence of latex allergy among greenhouse workers
J Allergy Clin Immunol
(1995) - et al.
A cluster of anaphylactic reactions in children with spina bifida during general anesthesia: epidemiological features, risk factors, and latex hypersensitivity
J Allergy Clin lmmunol
(1994) - et al.
Specific immunotherapy with a standardized latex extract versus placebo in allergic healthcare workers
J Allergy Clin Immunol
(2000) - et al.
Characterization and standardization of a latex extract [abstract]
J Allergy Clin Immunol
(1996) - et al.
Inhalation challenge testing of latex-sensitive health care workers and the effectiveness of laminar flow HEPA-filtered helmets in reducing rhinoconjunctival and asthmatic reactions
J Allergy Clin Immunol
(1998) - et al.
Allergy to latex rubber
Ann Intern Med
(1995) - et al.
Natural rubber latex allergy
Allergy
(1996) - et al.
Anaphylactic reactions during general anesthesia among pediatric patients
MMWR Morb Mortal Wkly Rep
(1990)
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2016, Disease-a-MonthAsthma in the Workplace
2015, Murray and Nadel's Textbook of Respiratory Medicine: Volume 1,2, Sixth Edition
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Reprint requests: Joaquín Sastre, MD, PhD, Fundación Jiménez Díaz, Servicio de Alergia, Av. Reyes Católicos 2, 28040 Madrid, Spain.