Echocardiographic Features of Primary Pulmonary Hypertension*,**,*
Section snippets
Study Population
We analyzed 51 consecutive patients referred to the University of Michigan for evaluation of known or suspected pulmonary hypertension or who were initially diagnosed to have PPH at the University of Michigan after referral for another presumed diagnosis (Table 1).All patients underwent a detailed history, physical examination, electrocardiography, chest radiography, and comprehensive transthoracic echocardiography (TTE), including Doppler studies. The diagnosis of PPH was established by use of
Patient Demographics
Demographic data are presented in Table 1. The female-to-male ratio was 7.5:1. Of the total patients, 78% were in New York Heart Association functional class III or IV. The mean time from the onset of the initial symptoms to diagnosis was 20.6 ± 20.2 months (median 12), with a range from 1 to 84 months, confirming that the diagnosis of PPH is usually made late in the course of disease.
TTE was available in all 51 subjects. Additionally, contrast TTE was available in 24 and TEE in 5. TEE
DISCUSSION
PPH is a rare disease of the pulmonary vasculature that primarily affects otherwise healthy young adults. It usually follows a rapidly fatal course and has a median survival of only 2.8 years after diagnosis. Five-year survival rate is 34%.23 Because of the nonspecific symptoms and the subtlety of the signs of less advanced disease, the mean length of time from the onset of symptoms to definitive diagnosis averages 2 years.1 A high level of clinical suspicion is important for prompt diagnosis
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Large animal preclinical investigation into the optimal extracorporeal life support configuration for pulmonary hypertension and right ventricular failure
2023, Journal of Heart and Lung TransplantationCitation Excerpt :Briefly, the model achieved an RVSP of 93 ± 17 mm Hg after 60 to 70 days. Transthoracic echocardiography noted characteristics of a pressure-overloaded state including increased interventricular septal flattening and bowing, RV dilatation, and D-shaped LV (Figure 2A).27 Consistent with these findings, the necropsy at end of this study demonstrated substantial increase in RV mass from normal values reported in previous literature (Figure 2C, 0.66 ± 0.08, N = 10 vs 0.35 ± 0.01).28
Chamber Attention Network (CAN): Towards interpretable diagnosis of pulmonary artery hypertension using echocardiography
2023, Journal of Advanced ResearchPulmonary Artery Acceleration Time in Young Adulthood and Cardiovascular Outcomes Later in Life: The Coronary Artery Risk Development in Young Adults Study
2020, Journal of the American Society of EchocardiographySafety and Feasibility of Performing Pericardiocentesis on Patients with Significant Pulmonary Hypertension
2019, Cardiovascular Revascularization Medicine
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From the Division of Cardiology, Department of Internal Medicine, University of Michigan, Ann Arbor, Mich.
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Reprint requests: William F. Armstrong, MD, University of Michigan Hospital, Division of Cardiology, Women’s L3119, 1500 E Medical Center Dr, Ann Arbor, MI 48109-0273. E-mail: [email protected].
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0894-7317/99 $8.00+0 27/1/99069