Elsevier

Respiratory Medicine

Volume 102, Issue 2, February 2008, Pages 316-319
Respiratory Medicine

CASE REPORT
Complete remission of nodular pulmonary Langerhans cell histiocytosis lesions induced by 2-chlorodeoxyadenosine in a non-smoker

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Summary

Pulmonary Langerhans cell histiocytosis (LCH) is an uncommon cause of interstitial lung disease. Corticosteroids and chemotherapeutic agents are frequently used to treat symptomatic patients but their efficacy is unclear. We describe a 66-year-old with biopsy-proven pulmonary and systemic LCH, whose pulmonary abnormalities responded dramatically to treatment with 2-chlorodeoxyadenosine (2-CdA). We propose that, in selected cases, 2-CdA should be considered in the management of pulmonary LCH.

Keywords

Langerhans cell histiocytosis
Cigarette smoking
2-Chlorodeoxyadenosine
Interstitial lung disease
Lung nodules

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