Elsevier

Respiratory Medicine

Volume 101, Issue 8, August 2007, Pages 1696-1701
Respiratory Medicine

The association of OSA with insulin resistance, inflammation and metabolic syndrome

https://doi.org/10.1016/j.rmed.2007.02.025Get rights and content
Under an Elsevier user license
open archive

Summary

Obstructive sleep apnea (OSA) shares many cardiovascular risk factors with metabolic syndrome, including obesity, hypertension, insulin resistance, and pro-inflammatory state. This study aimed to examine the possible association of OSA severity with insulin resistance, inflammation and the metabolic syndrome.

Ninety eight patients suspected for OSA (54.9±13.1 years) were studied. Overnight polysomnography and blood sampling was taken for glucose, insulin, high-density lipoprotein(HDL)-cholesterol, triglycerides, high-sensitivity C-reactive protein (Hs-CRP), and serum amyloid A (S-AA). Insulin resistance was estimated by the homeostatic model assessment (HOMA). Each patient was assigned a metabolic score according to the number of discrete components of metabolic syndrome identified, and categorized by OSA severity.

Nine patients had primary snoring, nine had mild, 27 moderate and 53 severe OSA. Metabolic score increased from 1.56±1.01 to 2.92±1.20 with OSA severity (p = 0.004), and was correlated independently with apnea hypopnea index (AHI; r = 0.432, p = 0.001) and with body mass index (BMI; r = 0.518 p = 0.001). Hs-CRP increased from 3.44±4.25 to 5.87±4.76 mg/dL with OSA severity (p = 0.066) and correlated with AHI (r = 0.348; p = 0.002). Insulin resistance, correlated significantly with AHI (r = 0.390 p = 0.021).

Inflammation, insulin resistance and metabolic syndrome increase with OSA severity. The number of cardinal features of metabolic syndrome increases with an increase in OSA severity, regardless of the BMI.

KEYWORDS

Sleep apnea syndrome
Nocturnal hypoxia
Metabolic syndrome

Cited by (0)

1

Contributed equally to this work.