Early inflammation in the airways of a cystic fibrosis foetus☆

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Abstract

In cystic fibrosis patients, inflammation is often considered to be secondary to chronic infections. In the present study, we show increased levels of pro-inflammatory proteins in the lungs of a cystic fibrosis foetus compared to the lungs of two normal foetuses. Our findings suggest therefore the existence of an early intrinsic pro-inflammatory state in cystic fibrosis airways.

Keywords

CFTR
NF-κB
Pro-inflammatory cytokines

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☆

C. V. was supported by a F. R. I. A. (“Fond pour la Recherche Industrielle et Agricole”) fellowship. C. O. and L. de L. are Research Associates at the National Fund for Scientific Research (FNRS, Belgium). This work was supported by grants from National Fund for Scientific Research and Foundation Forton of Belgium. Some data have been previously reported in the form of an abstract (international meeting “Cystic Fibrosis and Anionic Channelopathies”, Brussels, September 8, 2006 and the 28th European CF Conference, June 22–25, 2005, Crete, Greece [1]).

Copyright © 2006 European Cystic Fibrosis Society. Published by Elsevier B.V. All rights reserved.