Mechanisms of allergy and clinical immunologyOxidative stress–induced mitochondrial dysfunction drives inflammation and airway smooth muscle remodeling in patients with chronic obstructive pulmonary disease
Key words
Abbreviations used
Cited by (0)
The MRC-ABPI COPD-MAP consortium (G1001367/1) funded the clinical aspects of this project; in this regard we are also grateful to Professor M. Polkey (RBHFT) for his support for these aspects. Gene arrays were performed by Janssen Research & Development. I.M.A. and P.J.B. are supported by Wellcome Trust grant 093080/Z/10/Z. C.H.W. is a RCUK Research Fellow. This project was supported by the NIHR Respiratory Disease Biomedical Research Unit at the Royal Brompton and Harefield NHS Foundation Trust and Imperial College London. The views expressed in this publication are those of the author(s) and not necessarily those of the NHS, The National Institute for Health Research or the Department of Health.
Disclosure of potential conflict of interest: M. P. Murphy has a board membership, consultant arrangements, and stock/stock options with Antipodean Pharmaceuticals and has patents on MitoQ. K. F. Chung is on advisory boards for GlaxoSmithKline, AstraZeneca, Novartis, and Johnson & Johnson; has received research support from the Medical Research Council, European Union, Innovative Medicines Initiative, and National Institutes of Health; and has received payment for lectures from AstraZeneca and Merck. I. M. Adcock has received research support from Medical Research Council–Association of the British Pharmaceutical Industry COPD MAP (grant no. G1001367/1), the Wellcome Trust (grant no. 093080/Z/10/Z), DMT, and the European Research Council; has received payment for lectures from MSD; has a board membership with Almirall; has received payment for development of educational presentations from Webinar; and has received travel support from Boehringer Ingelheim, GlaxoSmithKline, and MSD. The rest of the authors declare that they have no relevant conflicts of interest.
- ∗
These authors contributed equally to this work.
- ‡
The COPDMAP Collaborators are shown in the acknowledgments section.