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Disclosure of potential conflict of interest: E. A. Hoffman has received research support and travel support from the National Institutes of Health (NIH) and has stock/stock options in VIDA Diagnostics. M. Castro has received research support from the NIH (SARP); has consultancy arrangements with Asthmatx/Boston Scientific, Genentech, IPS/Holaira, Pulmagen, and Sanofi Aventis; has received one or more grants from or has one or more grants pending with Asthmatx/Boston Scientific, Amgen, Ception/Cephalon/Teva, Genentech, MedImmune, Merck, Novartis, GlaxoSmithKline, Sanofi Aventis, Vectura, Next Bio, and KaloBios; has received one or more payments for lecturing from or is on the speakers' bureau for Merck, GlaxoSmithKline, Genentech, Asthmatx/Boston Scientific, and Boehringer Ingelheim; and has received royalties from Elsevier. A. Sheshadri declares no relevant conflicts of interest.

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