Asthma and lower airway diseaseCan computed tomography help us identify asthmatic phenotypes?
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Advances in adult asthma diagnosis and treatment in 2014
2015, Journal of Allergy and Clinical ImmunologyCitation Excerpt :Cluster 3 had severe lung function deficit and air trapping; its subjects tended to be more obese and had more airway remodeling, as evidenced by increased bronchial wall volumes and narrowed airway lumens. As noted in an accompanying editorial, although these clusters do not correspond to previously described clinical phenotypes, a biomarker like quantitative computed tomography might add to our understanding of the pathophysiology of remodeling and allow assessment of the efficacy of therapeutic interventions, such as bronchothermoplasty.53 Baines et al54 identified 6 gene biomarkers from induced sputum with expression levels that distinguished asthma inflammatory phenotypes and treatment responses.
Autopsy and imaging studies of mucus in asthma: Lessons learned about disease mechanisms and the role of mucus in airflow obstruction
2018, Annals of the American Thoracic SocietyAirway evaluation with multidetector computed tomography post-processing methods in asthmatic patients
2016, Advances in Experimental Medicine and BiologyShould lung biopsies be performed in patients with severe asthma?
2015, European Respiratory Review
Disclosure of potential conflict of interest: E. A. Hoffman has received research support and travel support from the National Institutes of Health (NIH) and has stock/stock options in VIDA Diagnostics. M. Castro has received research support from the NIH (SARP); has consultancy arrangements with Asthmatx/Boston Scientific, Genentech, IPS/Holaira, Pulmagen, and Sanofi Aventis; has received one or more grants from or has one or more grants pending with Asthmatx/Boston Scientific, Amgen, Ception/Cephalon/Teva, Genentech, MedImmune, Merck, Novartis, GlaxoSmithKline, Sanofi Aventis, Vectura, Next Bio, and KaloBios; has received one or more payments for lecturing from or is on the speakers' bureau for Merck, GlaxoSmithKline, Genentech, Asthmatx/Boston Scientific, and Boehringer Ingelheim; and has received royalties from Elsevier. A. Sheshadri declares no relevant conflicts of interest.