Asthma and lower airway diseaseComparison of childhood wheezing phenotypes in 2 birth cohorts: ALSPAC and PIAMA
Section snippets
Study populations: ALSPAC and PIAMA
ALSPAC is a population-based birth cohort study that recruited 14,541 pregnant women resident in Avon, United Kingdom, during 1991 and 1992.29, 30 Study mothers were sent a self-completion questionnaire about the health of their children at 6, 18, 30, 42, 54, 69, 81, and 91 months after birth. The study protocol was approved by the ALSPAC Law and Ethics Committee (Institutional Review Board 00003312) and the local research ethics committee.
PIAMA is a multicenter birth cohort study that selected
Results
Characteristics of the study population of the ALSPAC study and the PIAMA study are shown in Table I. In ALSPAC, 11,740 children returned at least 2 questionnaires, and 5760 (49.1%) had complete reports of wheeze at all 8 time points. Children with complete data were less likely than children with incomplete data to wheeze during childhood and to have a mother with atopy. In PIAMA, 3789 children returned at least 2 questionnaires, and 2810 (74.2%) had complete reports of wheeze. Children with
Discussion
In this study, we compared early childhood wheezing phenotypes identified by using LLCA in 2 independent birth cohorts. The never/infrequent, persistent, and late-onset wheezing phenotypes identified in PIAMA had similar trajectories to the phenotypes with the same names previously identified in ALSPAC. The transient early wheezing phenotype identified in PIAMA seemed to represent a combination of the prolonged early and transient early phenotypes reported in ALSPAC. The intermediate-onset
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The PIAMA study is supported by the Dutch Asthma Foundation (grant nos. 3.4.01.26, 3.2.06.022, 3.4.09.081, and 3.2.10.085CO), the ZonMw (a Dutch organization for health research and development; grant no. 912-03-031), and the Ministry of the Environment. The UK Medical Research Council, the Wellcome Trust, and the University of Bristol provide core support for ALSPAC. R.G. was supported by the UK Medical Research Council (grant no. 0401540).
Disclosure of potential conflict of interest: J. Henderson receives research support from the UK Medical Research Council. G. H. Koppelman receives research support from GlaxoSmithKline and the Netherlands Asthma Foundation. D. S. Postma has consultant arrangements with Nycomed and receives research support from Top Institute Pharma and AstraZeneca. J. A. Sterne receives research support from the Medical Research Council-UK. R. Granell receives research support from the Medical Research Council-UK. The rest of the authors have declared that they have no conflict of interest.
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These authors contributed equally to this work.