Clinical lung and heart/lung transplantationComparison of Induced Sputum and Bronchoalveolar Lavage in Lung Transplant Recipients
Section snippets
Subjects
Consecutive LTRs were included from April 2002 to April 2005. We limited study eligibility to double-lung or heart–lung transplant patients who were either clinically healthy (i.e., no clinical symptom, FEV1 ≥80% of baseline, nitrogen slope <3% and normal leukocyte counts), or diagnosed as having BOS according to the ISHLT staging criteria.9 Single-lung transplant recipients were excluded because it could not be ascertained clearly whether the sputum sample came from the allograft or the native
Patients
Thirty-four LTRs (20 males and 14 females) and 19 controls were included in the study. Mean time since transplantation was 6 years and 5 months (6 years for non-BOS patients, 7 years and 11 months for BOS patients).
Thirty-two patients had undergone double-lung transplantation and 2 had heart–lung transplantation. The primary pulmonary diagnoses were cystic fibrosis (n = 20), bronchiectasis (n = 3), emphysema (n = 7), Langerhans cell histiocytosis (n = 2), pulmonary fibrosis (n = 1) and
Discussion
In this study, we have confirmed that recovering bronchial cells with sputum induction provides information for monitoring LTR respiratory tract inflammation. Furthermore, this procedure was successful in 84% of cases, a proportion even higher than that usually reported in asthma where IS has been extensively studied and validated.20, 21 This high percentage of IS success was to be expected in this LTR population that consisted of mainly cystic fibrosis patients. The diagnostic interest of IS
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2024, eBioMedicineLung function and airway inflammation monitoring after hematopoietic stem cell transplantation
2013, Respiratory MedicineCitation Excerpt :On the other hand, Lahzami et al. did not find any change in FeNO over a one-year follow-up after HSCT even if the patients showed signs of small airway dysfunction [33]. High sputum neutrophil counts have been linked to an irreversible airway obstruction in chronic obstructive pulmonary disease (COPD) [19] and BO following lung transplantation [34]. Neutrophilic airway inflammation is also seen in diseases with intense airway bacterial load such as bronchiectasis [35] and cystic fibrosis [36].
Comparison of serum KL-6 versus bronchoalveolar lavage neutrophilia for the diagnosis of bronchiolitis obliterans in lung transplantation
2011, Journal of Heart and Lung TransplantationA 2010 working formulation for the standardization of definitions of infections in cardiothoracic transplant recipients
2011, Journal of Heart and Lung TransplantationPrognostic Value of Bronchoalveolar Lavage Neutrophilia in Stable Lung Transplant Recipients
2009, Journal of Heart and Lung TransplantationCitation Excerpt :Moreover, our data suggest that further evaluation of initially stable recipients may provide important clues about genuine factors contributing to the epithelial damage and the fibroproliferative response in BOS. Interestingly, BAL neutrophilia has been shown to correlate with exhaled nitric oxide (eNO) levels regardless of BOS status, and induced sputum neutrophilia allows discrimination of BOS from non-BOS recipients.36,37 This suggests that serial assessment of these markers may be helpful to non-invasively monitor for the development of overt airway inflammation and allow an earlier diagnosis of BOS.38
Relation of sputum neutrophilia to the development of chronic lung allograft dysfunction after lung transplantation
2021, Clinical Transplantation
Supported by ARARD, Vaincre la Mucoviscidose and Assistance Publique—Hôpitaux de Marseille.