ISHLT special reportReport of the ISHLT Working Group on Primary Lung Graft Dysfunction Part V: Predictors and Outcomes
Section snippets
Short- and long-term outcomes of PGD
The recognition of outcomes of PGD is essential for determination of the impact of this early post-operative problem on short- and long-term prognosis. PGD remains responsible for significant early morbidity and mortality after lung transplantation.11 Relevant clinical outcomes of PGD include length of mechanical ventilation (LOV), ICU length of stay (LOS), hospital length of stay (hLOS), mortality, short- and long-term survival, cost, functional status and incidence of bronchiolitis obliterans
Predictors/scores of outcomes of PGD
Although there is more information on the prediction of development of PGD, there are limited data on the prediction of outcomes of PGD once it is present. Certain cellular, molecular, physiologic and clinical variables have been associated with outcomes in PGD in studies that typically included a small number of patients.
Fisher et al reported a significant association between high donor IL-8 concentration in bronchoalveolar lavage fluid and the development of early graft dysfunction and
References (21)
- et al.
Primary graft failure following lung transplantation
Chest
(1998) - et al.
Clinical risk factors for primary graft failure following lung transplantation
Chest
(2003) - et al.
Non-immune acute graft injury after lung transplantation and the risk of subsequent bronchiolitis obliterans syndrome (BOS)
J Heart Lung Transplant
(2002) - et al.
Acute pulmonary edema after lung transplantationthe pulmonary reimplantation response
Chest
(1999) - et al.
Reperfusion injury significantly impacts clinical outcome after pulmonary transplantation
Ann Thorac Surg
(2000) - et al.
Primary graft failure following lung transplantationpredictive factors of mortality
Chest
(2002) - et al.
Respiratory failure after lung transplantation
Chest
(2003) - et al.
The registry of the International Society for Heart and Lung Transplantationtwentieth official adult lung and heart-lung transplant report-2003
J Heart Lung Transplant
(2003) - et al.
Impact of primary graft failure on outcomes following lung transplantation
Chest
(2005) - et al.
The “injury response”a concept linking nonspecific injury, acute rejection, and long-term transplant outcomes
Transplant Proc
(1997)
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History of Lung Transplantation
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2020, Journal of Heart and Lung TransplantationElevated pre-transplant left ventricular end-diastolic pressure increases primary graft dysfunction risk in double lung transplant recipients
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2019, Critical Care ClinicsCitation Excerpt :The radiologic findings spare the native lung in cases of single-lung transplantation, which helps to distinguish this syndrome from other clinical entities, such as left ventricular failure or ARDS. Grade 3 PGD occurs in 15% to 20% of patients and is associated with prolonged mechanical ventilation, increase the intensive care unit (ICU) length of stay, and 30-day mortality up to 50%.6–9 In addition, late graft dysfunction at 48- and 72-hour time points is associated with higher mortality than PGD 3 in the first 24 hours, which is usually transient and has less impact on the clinical outcome.10
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