Case Report
Diagnostic and therapeutic challenges in a liver transplant recipient with central nervous system invasive aspergillosis☆

https://doi.org/10.1016/j.diagmicrobio.2012.05.001Get rights and content

Abstract

This is a case report of central nervous system (CNS) invasive aspergillosis (IA) in a liver transplant recipient, which illustrates the utility of enzyme-based diagnostic tools for the timely and accurate diagnosis of IA, the treatment challenges and poor outcomes associated with CNS IA in liver transplant recipients.

Section snippets

Acknowledgments

This manuscript was, in part, supported by a National Institute of Health K24, AI85118 grant.

References (20)

  • C.A. Bonham et al.

    Central nervous system lesions in liver transplant recipients: prospective assessment of indications for biopsy and implications for management

    Transplantation

    (1998)
  • B. De Pauw et al.

    Revised definitions of invasive fungal disease from the European Organization for Research and Treatment of Cancer/Invasive Fungal Infections Cooperative Group and the National Institute of Allergy and Infectious Diseases Mycoses Study Group (EORTC/MSG) Consensus Group

    Clin Infect Dis

    (2008)
  • D.W. Denning

    Therapeutic outcome in invasive aspergillosis

    Clin Infect Dis

    (1996)
  • C. Garcia-Vidal et al.

    Epidemiology of invasive mold infections in allogeneic stem cell transplant recipients: biological risk factors for infection according to time after transplantation

    Clin Infect Dis

    (2008)
  • H.J. Johnson et al.

    Voriconazole pharmacokinetics in liver transplant recipients

    Antimicrob Agents Chemother

    (2010)
  • R.R. Klont et al.

    Utility of Aspergillus antigen detection in specimens other than serum specimens

    Clin Infect Dis

    (2004)
  • S.J. Lin et al.

    Aspergillosis case fatality rate: Systematic Review of the Literature

    Clin Infect Dis

    (2001)
  • I. Lutsar et al.

    Voriconazole concentrations in the cerebrospinal fluid and brain tissue of guinea pigs and immunocompromised patients

    Clin Infect Dis

    (2003)
  • M. Machetti et al.

    Antigen detection in the diagnosis and management of a patient with probable cerebral aspergillosis treated with voriconazole

    Transpl Infect Dis

    (2002)
  • K.A. Marr et al.

    Combination antifungal therapy for invasive aspergillosis

    Clin Infect Dis

    (2004)
There are more references available in the full text version of this article.

Cited by (0)

☆

Conflicts of Interest: D.N. has received research grants from Pfizer. S.S. has received research grants from Pfizer, Merck and Astellas and has served on advisory boards for Merck. K.A.M. has received grant support from Astellas, Merck and Pfizer and has served on advisory boards / or as consultant for Astellas, Basilea, Merck, Pfizer, Schering Plough. All other authors: No conflicts of interest.

View full text
Copyright © 2012 Elsevier Inc. All rights reserved.