Original articleA Prospective Safety Study of a Low-Dose Propofol Sedation Protocol for Colonoscopy
Section snippets
Methods
This study protocol was reviewed and approved by the institutional review board at St. Vincent’s Hospitals. The trial was a prospective study of 100 patients undergoing elective colonoscopy at either St. Vincent’s Carmel Hospital (Carmel, IN) or St. Vincent’s Hospital (Indianapolis, IN). All patients were referred through an open-access scheduling system. Patients were eligible to enter the study if they were between the ages of 18 to 75 years and were in American Society of Anesthesiology risk
Results
A total of 100 patients were enrolled in the study. Baseline characteristics of the study group are summarized in Table 2. In a questionnaire completed before the procedure, patients estimated that they would be discharged from the hospital an average of 66 ± 38 minutes after completion of the examination and they anticipated that the residual effects of sedation would persist for an average of 3.8 ± 4.8 hours.
Ninety-six patients received meperidine 50 mg and midazolam 1 mg, and the remaining 4
Discussion
The primary outcome measures in this study were designed to document the safety of the propofol protocol designed by Cohen et al7 for outpatient colonoscopy. Our secondary objectives were to document timely measures of efficiency, patient satisfaction, and adverse effects. The results of this study showed safe institution of this propofol-based protocol for colonoscopy. There were no serious adverse events such as bag mask ventilation, intubation, or hospitalization that occurred in this study.
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Cited by (43)
Position statement of the Catalan Society of Digestology on sedation in gastrointestinal endoscopy
2012, Gastroenterologia y HepatologiaBalanced propofol sedation for therapeutic GI endoscopic procedures: A prospective, randomized study
2011, Gastrointestinal EndoscopyCitation Excerpt :First, it allowed for precise titration of propofol, with a smaller bolus of doses to maintain the target level of sedation. Several prospective studies of BPS also have shown that the level of sedation is titrated readily to a moderate level of sedation, so that the actual incidence of deep sedation is quite low.17-20 Second, specific antagonists of benzodiazepines (flumazenil) and/or opioids (naloxone) are available.
Sedation: Not Quite That Simple
2010, Anesthesiology ClinicsCitation Excerpt :Such statements obviously confirm that these investigators, who are supposed to be experts on sedation in the emergency unit, lack the understanding of risks associated with propofol use. Similarly, a recent article on nurse-administered propofol sedation for gastrointestinal endoscopic procedures13 states that “when using a multidrug protocol with propofol, the clinician may be able to exploit the therapeutic actions of the individual agents while reducing the possibility of sedation dose-related complications.” This standpoint is contrary to the established principles of polypharmacy emphasizing that the risk of hypoxia, hypercarbia, and airway compromise are actually worsened when propofol is combined with benzodiazepines and/or opioids.
The randomized clinical trial of safety and efficacy of oral tramadol in patients undergoing colonoscopy
2021, Journal of Reports in Pharmaceutical SciencesEndoscopist-directed propofol is more efficient than anesthesiologist-administered propofol in patients at low-intermediate anesthetic risk
2020, European Journal of Gastroenterology and Hepatology
Submitted in part to American College of Gastroenterology Conference in October 2006 as an abstract.