Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease
Volume 1812, Issue 7, July 2011, Pages 760-768
Evaluation of urinary biomarkers of oxidative/nitrosative stress in adolescents and adults with Down syndrome☆
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Research highlights
► Urinary AGEs, diTyr, H2O2 and NOx could be used as oxidative stress biomarkers in DS. ► Urinary levels of 8-OHdG, 15-F2t-IsoP and TBARS are not altered in DS. ► Correlations with age were positive for diTyr and negative for Cr, TBARS, 15-F2t-IsoP and NOx in DS. ► Renal impairment could occur in DS and Cr adjustment may bias the results. ► Renal impairment due to hypothyroidism may bias the results in DS.
Abbreviations
8-OHdG
8-hydroxy-2′-deoxyguanosine
15-F2t-IsoP
isoprostane
AFU
arbitrary fluorescence units
AGEs
advanced glycation end-products
BHT
butylated hydroxytoluene
Cr
creatinine
DiTyr
dityrosine
DS
Down syndrome
ELISA
enzyme-linked immunosorbent assay
FOX-2
xylenol orange version-2
H2O2
hydrogen peroxide
HCl
hydrochloric acid
HPLC
high-performance liquid chromatography
HSA21
chromosome 21
JaICA
Japan Institute for the Control of Aging
MDA
1,1,3,3-tetraethoxypropane
NO
nitric oxide
NOx
total nitrite and nitrate
NS
not significant
SOD1
Cu/Zn superoxide dismutase
TBA
2-thiobarbituric acid
TBARS
thiobarbituric acid-reacting substances
VCl3
vanadium(III) chloride
Keywords
Down syndrome
Oxidative stress
Nitrosative stress
Biomarker
Hypothyroidism
Urine
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This study was supported by Fundación Inocente, Inocente.
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