Original articleGeneral thoracicManagement and Outcomes of Relapse After Treatment for Thymoma and Thymic Carcinoma
Section snippets
Patients and Methods
We reviewed our institutional database to identify all patients who underwent their initial surgical resection for thymoma and thymic carcinoma from January 1995 to December 2006 at Memorial Sloan-Kettering Cancer Center. Patients who had undergone prior resection elsewhere were excluded as details concerning their initial primary treatments could not be verified. A prior study on this cohort analyzed the predictors and patterns of recurrence, and this paper is presented as a companion study
Results
During the study period, 120 patients underwent their initial surgical resection for thymic tumors at our institution. Ninety-seven of these patients (81%) had histologically confirmed malignant thymoma, while 23 (19%) had thymic carcinoma. Of these initial 120 patients, 112 had follow-up data available and 25 patients (22%) developed relapse of disease (10 thymic carcinoma, 15 thymoma). Patient characteristics are shown in Table 1. Median follow-up for all patients was 51.4 months from initial
Comment
This study describes a series of patients with recurrent or progressive thymic malignancies treated over a relatively short interval using contemporary therapies. Although previous studies have suggested the superiority of surgical management, few have described the selection of patients or delineated the differences among the patients treated. The majority of these patients had undergone incomplete resections at the time of their initial surgery. Despite presenting with seemingly localized and
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