Original articleGeneral thoracicLung Transplantation and Coronary Artery Disease
Section snippets
Patients and Methods
This study was approved by the Institutional Review Board. The records of all patients who underwent lung transplantation at the University of California-Los Angeles from January 2000 to March 2010 were reviewed. During this period, 27 patients underwent lung transplantation and coronary revascularization and are the subject of this study.
Perioperative Characteristics of Patients With CAD and the Control Group
During the study period, 27 patients with critical coronary artery lesions and preserved left ventricular function underwent lung transplantation and coronary revascularization, and are therefore the subjects of this study. The perioperative characteristics of this group of patients are shown in Table 1. The waiting time for patients with CAD and the control group was similar. Thirteen of 27 patients were deemed suitable candidates for single lung transplantation and were therefore referred for
Comment
The findings of this study demonstrate that selected patients with CAD can undergo coronary revascularization and lung transplantation with acceptable short-term and medium- term outcomes. Our results are comparable with lung transplant recipients without CAD.
Several reports have examined the role of coronary revascularization in lung transplant recipients with CAD [7, 8, 9, 10]. Snell and colleagues [7] were the first group to report on 5 patients with clinically significant CAD who underwent
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Prior and Perioperative Revascularization Does Not Affect Survival in Lung Transplant Patients
2020, Annals of Thoracic SurgeryCitation Excerpt :Support for revascularization with LTx has been suggested by several authors.12,13 Sherman and colleagues7 compared 27 lung recipients who had undergone PCI or concomitant CABG with 81 control recipients, and, much like our findings, demonstrated similar survival and perioperative adverse events in the 2 groups. Parekh and colleagues12 found that in LTx with concomitant cardiac procedures, predominantly foramen ovale or atrial septal defect surgeries, similar 5-year survival was observed compared with that for patients without these concomitant procedures.
How important is coronary artery disease when considering lung transplant candidates?
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2016, Journal of Thoracic and Cardiovascular SurgeryCitation Excerpt :Some of these patients had undergone pretransplantation percutaneous coronary intervention, and many had required concomitant CABG. Sherman and colleagues3 reported on 27 patients who had undergone concomitant CABG or pretransplantation percutaneous coronary intervention. Medium-term survival of this cohort was similar to that for historical cohorts.
Impact of pre-operative coronary artery disease on cardiovascular events following lung transplantation
2016, Journal of Heart and Lung TransplantationCitation Excerpt :The interval between coronary angiography and lung transplantation was calculated from the date of the left-heart catheterization procedure to the transplant date. Given the evidence showing acceptable clinical outcomes in lung transplant recipients with sub-clinical CAD irrespective of pre-operative coronary revascularization,9–13 none of our patients with sub-clinical CAD underwent coronary revascularization before or at the same time as lung transplant. Clinical events were examined by searching through the medical record database, lung transplantation registry records, and the Social Security Death Index.
Contra-indications of lung transplantation: Evolving limits?
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