Original articleGeneral thoracicOpen Lung Biopsy for Diffuse Disease in Patients With and Without Previously Transplanted Solid Organs
Section snippets
Patients and Methods
The study was approved by the institutional review board at the Favaloro Foundation.
The medical records of all patients who underwent SLB between March 2004 and March 2009 were reviewed. Data collected and analyzed included patient demographics, radiographic findings, operative reports, pathologic and microbiologic results, and change in therapy after SLB.
Results
Sixty patients underwent SLB during the study period. Baseline demographics are shown in Table 1. Thirty-four patients (57%) had a history of a solid-organ transplant. Fourteen were lung transplants (41%), 8 patients had kidney transplants (23%), 6 had heart transplants (18%), 5 had heart-lung transplants (15%), and 1 patient had a liver transplant (3%). The median elapsed time from the time of transplantation to SLB was 1,290 days (279 to 2,043 days). The median follow-up time was 164.64 days
Comment
Surgical lung biopsy is considered the best method for reaching a correct and specific diagnosis in DLD [14]. However, despite advances in surgical techniques, particularly the adoption of thoracoscopy, SLB still has substantial morbidity and mortality [9, 10]. The rate of treatment change after SLB varies in the literature from 8% to almost 85% [3, 4, 5, 8, 15]. However, none of the series reported in the literature have compared the rate of treatment change in solid-organ transplant
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Diffuse lung disease
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Invited commentary
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