ReviewThe Role of Surgery in the Management of Thymoma: A Systematic Review
Section snippets
Literature Search Strategy
A search of the MEDLINE database was performed with the keywords “thymoma” and “surgery” using the following limits: English language only, humans only, and published after 1981 (the year in which the Masaoka staging system was published). The Cochrane database, the National Guideline Clearinghouse (http://www.guideline.gov/index.asp) and abstracts from the 2004 and 2007 American Association of Thoracic Surgery meetings were also searched for English language abstracts or manuscripts related to
Literature Search Results
Our search strategy yielded 616 abstracts. Using our selection criteria we recovered a single prospective, randomized controlled trial and 23 retrospective series with between 40 and 1,093 patients. The patients in these studies were subjected to various combinations of surgery, radiotherapy, and chemotherapy. Patients within and between studies were very heterogeneous with respect to treatment protocols. Several small case series of between 1 and 22 patients were used in our discussion of
Comment
A significant limitation to generation of evidenced-based recommendations in the management of rare diseases is the paucity of prospective data on which to soundly base those recommendations. In the case of thymomas (with a single exception) all of the English language literature consists of retrospective case series with inconsistently applied treatment regimens. Notwithstanding the fact that surgeons may rarely encounter such diseases, treatment should be based on the best available evidence.
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Giant thymoma with myasthenia gravis: A case report
2023, Asian Journal of SurgeryPostoperative radiotherapy for completely resected thymoma: Differing roles in masaoka stage II and stage III disease
2022, Asian Journal of SurgeryCitation Excerpt :We compared OS, DFS, recurrence, and prognostic factors of completely resected stage II and III thymoma patients treated with or without PORT. Previous studies have reported that the average 10-year DFS of thymomas was 85% in stage II disease and 65% in stage III disease.25 In this study, the 10-year DFS was 78% for stage II thymoma and 60% in stage III thymoma, similar to findings previously reported in the literature.
Robotic-assisted minimally invasive thymectomy for myasthenia gravis with thymoma
2022, JTCVS TechniquesComparative effectiveness and cost-efficiency of surgical approaches for thymectomy
2020, Surgery (United States)