Stimuli-induced superoxide radical generation in vitro by human alveolar macrophages from smokers: Modulation by n-acetylcysteine treatment in vivo
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Benefits of high-dose N-acetylcysteine to exacerbation-prone patients with COPD
2014, ChestCitation Excerpt :Previous in vivo and in vitro studies supported the theory of an antioxidant and antiinflammatory effect of NAC in COPD, showing that NAC could reduce hydrogen peroxide (H2 O2)-induced damage in epithelial cells,21 attenuate airway wall epithelial thickening, and reduce secretory cell hyperplasia.22,23 Yet, in vivo studies have demonstrated the antiinflammatory effect of NAC by showing a rise in GSH level in BAL,24 a decrease exhaled H2 O2 levels,25 and a reduction of inflammatory markers in smokers.26 In fact, COPD exacerbation is multifactorial, and the mucolytic effect of NAC is salient in exacerbation-susceptible patients with COPD because their consistently inflamed ciliated epithelial cells in the airway are the preferred site for bacterial attachment.27
Oxidative stress in bronchopulmonary disease: Contribution of N-acetylcysteine (NAC)
2005, Revue de Pneumologie CliniqueAre anti-oxidant and anti-inflammatory treatments effective in different subgroups of COPD? A hypothesis
1998, Respiratory MedicineThe role of N-acetylcysteine in the treatment of chronic obstructive pulmonary disease
1995, Netherlands Journal of MedicineSuperoxide formed from cigarette smoke impairs polymorphonuclear leukocyte active oxygen generation activity
1992, Archives of Biochemistry and BiophysicsMultiple defects in arachidonate metabolism in alveolar macrophages from young asymptomatic smokers
1989, The Journal of Laboratory and Clinical Medicine