Elsevier

Human Pathology

Volume 23, Issue 11, November 1992, Pages 1216-1223
Human Pathology

Original contribution
Pulmonary vascular involvement in sarcoidosis: A report of 40 autopsy cases

https://doi.org/10.1016/0046-8177(92)90288-EGet rights and content

Abstract

We examined pulmonary vascular involvement in 40 autopsy cases of sarcoidosis. In these cases granulomatous involvement was observed at all levels from large elastic pulmonary arteries to venules, and venous involvement was more prominent than arterial involvement. The extent of granulomatous vascular involvement was related to that of parenchymal granuloma. No significant difference was found between upper and lower lobes in the incidence of granulomatous vascular involvement. The distribution of granulomata in the blood vessels was segmental and adventitial, and medial involvement was prominent in the larger vessels. Healed lesions of granulomatous vascular involvement also were observed at various levels in blood vessels. Prominent granulomatous involvement was found in the lymphatic capillaries and collecting lymphatic vessels in lungs with sarcoidosis. Serial sections of the lungs demonstrated interstitial granuloma directly connecting the lymphatic capillaries around small blood vessels. Granulomatous involvement in vasa vasorum and lymphatic capillaries is likely to be an important factor in the pathogenesis of granulomatous vascular involvement in lungs with sarcoidosis. The present study suggests that granulomatous vascular involvement and its sequelae may contribute to the development of pulmonary sarcoidosis.

References (16)

  • JR Thompson

    Vascular changes in sarcoidosis

    Dis Chest

    (1966)
  • A Churg et al.

    Necrotizing sarcoid granulomatosis

    Chest

    (1979)
  • CB Carrington et al.

    Structure and function in sarcoidosis

    Ann N Y Acad Sci

    (1976)
  • Y Rosen et al.

    Granulomatous pulmonary angiitis in sarcoidosis

    Arch Pathol Lab Med

    (1977)
  • T Yamaguchi et al.

    A histologic and histometric study of transbronchial lung biopsy in pulmonary sarcoidosis

    Nippon Kyobu Shikkan Gakkai Zashi

    (1986)
  • T Takemura et al.

    Pulmonary vascular involvement in sarcoidosis: Granulomatous angiitis and microangiopathy in transbronchial lung biopsies

    Virchows Arch [A]

    (1991)
  • JP Battesti et al.

    Chronic cor pulmonale in pulmonary sarcoidosis

    Thorax

    (1978)
  • J Turiaf et al.

    Sarcoidosis involving large pulmonary arteries

There are more references available in the full text version of this article.

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Supported in part by a grant from the Intractable Diseases Research Committee and the Interstitial Pulmonary Disease Research Committee, Ministry of Health and Welfare of Japan.

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