Frontiers reviewNO in the lung
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Treatment of Obstructive Sleep Apnea-Hypopnea Syndrome With a Mandible Advanced Device Increases Nitric Oxide Release and Ameliorates Pulmonary Hypertension in Rabbits
2021, Journal of Oral and Maxillofacial SurgeryVentilation causes pulmonary vascular dilation and modulates the NOS and VEGF pathway on newborn rats with CDH
2015, Journal of Pediatric SurgeryCitation Excerpt :Our results showed a decrease of NOS2 expression in CDH group after ventilation, as reported in the study above. Considering that NOS2 is activated by inflammatory stimuli [52], we would expect that the change from a hypoxic intrauterine environment to a relatively hyperoxic as seen in our study, would lead to an overflow of free radicals by the production of superoxide and H2O2 [40], resulting in activation of the inflammatory cascade and upregulation of NOS2. The endothelium is the main regulator of vascular tone by producing vasodilators.
The effects of respiratory muscle training on respiratory mechanics and energy cost
2014, Respiratory Physiology and NeurobiologyCitation Excerpt :One potential contributor to increased exercise performance and increased respiratory efficiency in particular is the possibility of increased nitric oxide (NO) levels in the airways. NO is a potent bronchodilator (Adnot et al., 1995), and higher exhaled levels have been observed in athletes (Maroun et al., 1995) and during exercise (Chirpaz-Oddou et al., 1997; Maroun et al., 1995) and heavy breathing (West et al., 2005). While these results must be interpreted cautiously—higher exhaled NO concentration does not necessarily indicate higher rates of production—they at least suggest a link between airway NO levels, work of breathing, and subject fitness, which may be of particular interest when considering the effects of RMT.
Current Knowledge of Acute Lung Injury and Acute Respiratory Distress Syndrome
2012, Critical Care Nursing Clinics of North AmericaCitation Excerpt :Exogenous NO gas delivered via the airspaces is a selective pulmonary vasodilator in aerated portions of the lung, which cause blood flow to redistribute toward ventilated areas. This results in improved matching of perfusion to ventilation, and therefore arterial oxygenation, without causing concomitant systemic vasodilation.110–116 The effect of NO on oxygenation and pulmonary artery pressure may allow more time for the lungs to recover.
Hydrogen sulfide: Regulatory role on blood pressure in hyperhomocysteinemia
2010, Vascular PharmacologyInhaled nitric oxide exacerbated phorbol-induced acute lung injury in rats
2004, Pulmonary Pharmacology and Therapeutics