Cholesterol fractions and triglycerides in children and adults with down's syndrome
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Cited by (35)
DYRK1A overexpression decreases plasma lecithin: Cholesterol acyltransferase activity and apolipoprotein A-I levels
2013, Molecular Genetics and MetabolismCitation Excerpt :Moreover, healthy older individuals with DS show some classic biochemical risk factors for atherosclerosis but do not suffer from clinical cardiovascular alterations [9]. Individuals with DS present several metabolic lipid abnormalities [7,10–15], although serum lipoprotein profiles cannot completely explain the lower prevalence of cardiovascular disease. Studies have shown that younger individuals with DS have lower high-density lipoprotein (HDL) levels [11,13,14], altered lecithin:cholesterol acyltransferase (LCAT) activity [16] and HDL component apolipoprotein A-I (ApoA-I) levels [12].
Cardiovascular disorders among persons with down syndrome
2010, International Review of Research in Mental RetardationCitation Excerpt :In patients with Down syndrome, prevalence of overweight and obesity is significantly higher, compared to other patients with intellectual disabilities and to the general population, with a reported prevalence of obesity in adults with Down syndrome between 31 and 47% (Bell & Bhate, 1992; Melville, Cooper, McGrother, Thorp, & Collacott, 2005; Prasher, 1995). Although abnormalities in lipid metabolism, which are associated with high risk of premature atherosclerosis in the general population, are frequently seen in patients with Down syndrome (Dorner, Gaethke, Tolksdorf, Schumann, & Gustmann, 1984), coronary artery disease-related mortality is surprisingly low (Baird & Sadovnick, 1988). Histopathological investigations showed no increase in atherosclerosis, or even a total lack of atherosclerotic changes.
Network analyses of differentially expressed proteins in amniotic fluid supernatant associated with abnormal human karyotypes
2009, Fertility and SterilityCitation Excerpt :Apolipoprotein A1 levels were significantly decreased in AFS of both trisomy 18 and trisomy 21. Although decreased serum levels of apolipoproteins A1 have been frequently found in individuals with DS (18, 25–27), its decreased levels in trisomy 18 in our supernatant analysis might be partly because the amniotic fluid contained a myriad of fetal cells from various origins, or it was a maternal response to aneuploidy fetuses given the proximity of decidua to fetal membranes. Adaptor-related protein complex 3μ 2 subunit (AP3M2, AP-3μ) is a subunit of the heterotetrameric adaptor-related protein complex 3 (AP-3) that belongs to the adaptor complexes medium subunits family.
Oxidated low-density lipoproteins (oxLDL) and peroxides in plasma of down syndrome patients
2007, Archives of Gerontology and GeriatricsDoes Down's syndrome support the homocysteine theory of atherogenesis?. Experience in elderly subjects with trisomy 21
2006, Archives of Gerontology and GeriatricsAlteration of SREBP activation in liver of trisomy 21 fetuses
1999, Biochemical and Biophysical Research Communications