Cefoperazone versus combination antibiotic therapy of hospital-acquired pneumonia☆
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Consensus document on controversial issues for the treatment of hospital-associated pneumonia
2010, International Journal of Infectious DiseasesCitation Excerpt :The former approach should be used if patients are likely to be infected with MDR pathogens. In the guidelines from Brazil and Argentina,31 on the basis of an analysis of a few studies,44–46 the authors are convinced that monotherapy in the treatment of HAP without MDR strains reduces costs and unnecessary exposure to antibiotics . The more recent guidelines of the British Society for Antimicrobial Chemotherapy (BSAC)32 revised the results of 16 RCTs enrolling patients with HAP (but not exclusively) and comparing patients receiving monotherapy with combination therapy with an aminoglycoside.42,43,45,47–58
Antimicrobial treatment of hospital-acquired pneumonia
2005, Clinics in Chest MedicineInternational conference for the development of consensus on the diagnosis and treatment of ventilator-associated pneumonia
2001, ChestCitation Excerpt :There was general agreement that the number of previous days of hospitalization was a more important factor than the number of previous days of ventilation and that other factors concerning the individual patient must be considered before monotherapy is chosen, such as the absence of structural lung disease, the absence of corticotherapy, the absence of immunosuppression, and the absence of antibiotherapy in the last 3 months. Generally, antibiotic monotherapy has shown success rates and rates of superinfections and colonization by multiresistant microorganisms that are similar to those for combination therapy.81828384858687 But other studies have demonstrated that patients with severe infections by P aeruginosa and multiresistant Klebsiella spp or Acinetobacter spp are better treated with combination antibiotherapy, such as antipseudomonal β-lactam plus aminoglycoside.8889
The antibiotic treatment of community-acquired, atypical, and nosocomial pneumonias
1995, Medical Clinics of North AmericaAn approach to empiric therapy of nosocomial pneumonia
1994, Medical Clinics of North America
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This work was presented in part at the Fourteenth International Conference of Antibiotic Agents and Chemotherapy, Kyoto, Japan, June 26, 1985, and was supported in part by a grant from Pfizer Pharmaceuticals.