Abstract
Purpose
The purpose of this study was to examine changes in the prevalence of exercise intolerance, reduced muscle strength, and fatigue and the changes in these parameters in individual patients during a 2-year follow-up study.
Methods
Ninety sarcoidosis patients (62 males and 28 females; mean age: 46.0 ± 10.2 years) participated in a 2-year follow-up study. At the baseline and follow-up measurements, patients performed a 6-min walk test and elbow flexor muscle strength, quadriceps peak torque, and hamstrings peak torque tests. Maximal inspiratory pressure was recorded. All patients completed the Fatigue Assessment Scale.
Results
Both at baseline and follow-up, a substantial proportion of the patients showed a reduced 6-minute walk test (41.6 and 34.8 %, respectively), elbow flexor muscle strength (6.7 and 14.6 %), quadriceps peak torque (21.3 and 18 %), hamstrings peak torque (13.5 and 12.4 %), and maximal inspiratory pressure (45.9 and 48.6 %). The majority of the patients reported fatigue (86 and 77 %). These physical impairments remained stable during the follow-up period. The prevalence of these physical impairments in patients diagnosed with sarcoidosis <2 years before inclusion in this study was similar to that in patients with a longer history of the disease.
Conclusions
Exercise intolerance, muscle weakness, and fatigue are frequent problems in symptomatic sarcoidosis patients with a stable and persistent character. This study highlights that beyond medical treatment a rehabilitation program should be considered as adjunct therapy in the multidisciplinary management of sarcoidosis patients even though the achieved benefit needs future studies.
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Acknowledgments
This study was financially supported by a grant from the ild care foundation (Maastricht, the Netherlands; www.ildcare.eu). This is a nonrestricted educational grant.
Conflict of interest
The authors have reported to ‘Lung’ that no conflicts of interests exist with any companies/organizations whose products or services may be discussed in this article.
Clinical Trial
This study is registered at www.ClinicalTrials.gov with trial number NCT00854672.
Medical Ethics Committee
The study was approved by the Medical Ethics Committee of the Maastricht University Medical Centre (MEC 09-4-007).
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Marcellis, R.G.J., Lenssen, A.F., Kleynen, S. et al. Exercise Capacity, Muscle Strength, and Fatigue in Sarcoidosis: A Follow-Up Study. Lung 191, 247–256 (2013). https://doi.org/10.1007/s00408-013-9456-6
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DOI: https://doi.org/10.1007/s00408-013-9456-6