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FDG-PET in infectious lesions: The detection and assessment of lesion activity

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Abstract

The usefulness of FDG-PET in the detection of infectious foci and the assessment of lesion activity was evaluated. The study covered 24 patients with 25 FDG-PET studies, including lesions of bacterial, tuberculous and fungal origins. The FDG uptake was determined by the lesion to muscle ratio (LMR) on the static images. The time activity curves (TACs) were classified into four patterns based on both the existence of an initial peak and a slope thereafter. A high FDG uptake was observed in 23 of 25 lesions (92%). Two lesions, in which no abnormal uptake was noted, included one in the healing stage and the other consisting of a cavity with a thin wall. The acute active lesions showed higher LMRs than the chronic active or healing lesions (mean ± SD: 9.8 ± 3.6, 3.6 ±1.8 and 4.3 ± 1.7, respectively, p < 0.05), and they could be approximately distinguished by an LMR of 6. The patterns of the TACs in acute or chronic active lesions were either an increase without an initial peak or a plateau, while those in the healing lesions demonstrated predominantly an increase with an initial sharp peak. Our results indicated that FDG-PET is clinically useful in the detection of the infection of miscellaneous microorganisms as well as in the assessment of lesion activity.

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References

  1. Sasaki M, Ichiya Y, Kuwabara Y, Otsuka M, Tahara T, Fukumura T, et al. Ringlike uptake of [18F]FDG in brain abscess: A PET study.J Comp Assist Tomogr 14: 486–487, 1990.

    CAS  Google Scholar 

  2. Hanson MW, Glantz MI, Hoffman JM, Friedman AH, Burger PC, Schold SC, et al. FDG-PET in the selection of brain lesions for biopsy.J Comp Assist Tomogr 15: 796–801, 1991.

    Article  CAS  Google Scholar 

  3. Meyer MA, Frey KA, Schwaiger M. Discordance between F-18 fluorodeoxyglucose uptake and contrast enhancement in abrain abscess.Clin NuclMed 18: 682–684, 1993.

    CAS  Google Scholar 

  4. Kubota K, Matsuzawa T, Fujiwara T, Ito M, Hatazawa J, Ishiwata K, et al. Differential diagnosis of lung tumor with positron emission tomography: A prospective study.J Nucl Med 31: 1927–1933, 1990.

    PubMed  CAS  Google Scholar 

  5. Wahl RL, Quint LE, Greenough RL, Meyer CR, White RI, Orringer MB. Staging of mediastinal non-small cell lung cancer with FDG PET, CT, and fusion images: Preliminary prospective evaluation.Radiology 191: 371–377, 1994.

    PubMed  CAS  Google Scholar 

  6. Dewan NA, Gupta NC, Redepenning LS, Phalen JJ, Frick MP. Diagnostic efficacy of PET-FDG imaging in solitary pulmonary nodules.Chest 104: 997–1002, 1993.

    Article  PubMed  CAS  Google Scholar 

  7. Patz EF Jr, Lowe VL, Hoffman JM, Paine SS, Burrowes S, Coleman RE, et al. Focal pulmonary abnormalities: Evaluation with F-18 fluorodeoxy glucose PET scanning.Radiology 188: 487–490, 1993.

    PubMed  Google Scholar 

  8. Strauss LG, Conti PS. The application of PET in clinical oncology.J Nucl Med 32: 623–648, 1991.

    PubMed  CAS  Google Scholar 

  9. Patz EF Jr, Lowe VL, Hoffman JM, Paine SS, Harris LK, Goodman PC. Persistent or recurrent bronchogenic carcinoma: Detection with PET and 2-[F-18]-2-deoxy-D-glucose.Radiology 191: 379–382, 1994.

    PubMed  Google Scholar 

  10. Brudin LH, Valind S-O, Rhodes CG, Pantin CF, Sweatman M, Jones T, et al. Fluorine-18 deoxyglucose uptake in sarcoidosis measured with positron emission tomography.EurJ Nucl Med 21: 297–305, 1994.

    Article  CAS  Google Scholar 

  11. Tahara T, Ichiya Y, Kuwabara Y, Otsuka M, Miyake Y, Gunasekera RD, et al. High [F-18]-fluorodeoxy-glucose uptake in abdominal abscesses: A PET study.J Comp Assist Tomogr 13: 829–831, 1989.

    CAS  Google Scholar 

  12. Okazumi S, Enomoto K, Fukunaga T, Kikuchi T, Asano T, Isono K, et al. Evaluation of the cases of benign disease with high accumulation on the examination of F-18 fluorodeoxyglucose PET.KAKU IGAKU (Jpn J Nucl Med) 30: 1439–1443, 1993 (in Japanese).

    CAS  Google Scholar 

  13. Haberkorn U, Strauss LG, Dimitrakopoulou A, et al. PET studies of fluorodeoxyglucose metabolism in patients with recurrent colorectal tumors receiving radiotherapy.J Nucl Med 32: 1485–1490, 1991.

    PubMed  CAS  Google Scholar 

  14. Ichiya Y, Kuwabara Y, Otsuka M, Tahara T, Yoshikai T, Fukumura T, et al. Assessment of response to cancer therapy using Fluorine-18-fluorodeoxyglucose and positron emission tomography.J Nucl Med 32: 1655–1660, 1991.

    PubMed  CAS  Google Scholar 

  15. West J, Morton DJ, Esmann V, Stjernholm RL. Carbohydrate metabolism in leukocytes. VIII. Metabolic activities of the macrophage.Archive Biochem Biophys 124: 85–90, 1968.

    Article  CAS  Google Scholar 

  16. Borregaard NB, Herlin T. Energy metabolism of human neutrophils during phagocytosis.J Clin Invest 70: 550–557, 1982.

    Article  PubMed  CAS  Google Scholar 

  17. Weisdorf DJ, Craddock PR, Jacob HS. Glycogenolysis versus glucose transport in human granulocytes: Differential activation in phagocytosis and chemotaxis.Blood 60: 888–893, 1982.

    PubMed  CAS  Google Scholar 

  18. Daley JM, Shearer JD, Mastrofrancesco B, Caldwell MD. Glucose metabolism in injured tissue: A longitudinal study.Surgery 107: 187–192, 1990.

    PubMed  CAS  Google Scholar 

  19. Anderson RL, Wood WA. Carbohydrate metabolism in microorganisms.Ann Rev Microbiol 23: 539–578, 1969.

    Article  CAS  Google Scholar 

  20. Tischler ME, Fagan JM. Response to trauma of protein, amino acid, and carbohydrate metabolism in injured and uninjured rat skeletal muscles.Metabolism 32: 853–868, 1983.

    Article  PubMed  CAS  Google Scholar 

  21. Kubota R, Yamada S, Kubota K, Ishiwata K, Tamahashi N, Ido T. Intratumoral distribution of Fluorine-18-fiuorodeoxy-glucosein vivo: High accumulation in macrophages and granulation tissues studies by microautoradiography.J Nucl Med 33: 1972–1980, 1992.

    PubMed  CAS  Google Scholar 

  22. Som P, Atkins HL, Bandoypadhyay D, Fowler JS, MacGregor RR, Matsui K, et al. A fluorinated glucose analog, 2-fluoro-2-deoxy-D-glucose (F-18): Nontoxic tracer for rapid tumor detection.J Nucl Med 21: 670–675, 1980.

    PubMed  CAS  Google Scholar 

  23. Marchesi VT. Inflammation and healing.In Anderson’s Pathology, Kissane JM (ed.), 8th ed., Mosby, pp. 22–60, 1985.

  24. Staab EV, McCartney WH. Role of Gallium 67 in inflammatory Disease.Sem Nucl Med 8: 219–234, 1978.

    Article  CAS  Google Scholar 

  25. Hoffer P. Gallium: Mechanisms.J Nucl Med 21: 282–285, 1980.

    PubMed  CAS  Google Scholar 

  26. Sfakianakis GN, Al-Shikh W, Heal A, Rodman G, Zeppa R, Serafini A. Comparisons of scintigraphy with In- 111 leukocytes and Ga-67 in the diagnosis of occult sepsis.J Nucl Med 23: 618–626, 1982.

    PubMed  CAS  Google Scholar 

  27. Goodwin DA. Clinical use of In-111 leukocyte imaging.Clin Nucl Med 8: 36–38, 1983.

    Article  PubMed  CAS  Google Scholar 

  28. Kipper MS, Williams RJ. Indium-111 white blood cell imaging.Clin Nucl Med 8: 449–455, 1983.

    Article  PubMed  CAS  Google Scholar 

  29. Datz FL, Thome DA. Effect of chronicity of infection on the sensitivity of the In-111-labeled leukocyte scan.AJR 147: 809–812, 1986.

    PubMed  CAS  Google Scholar 

  30. Froelich JW, Swanson D. Imaging of inflammatory processes with labeled cells.Sem Nucl Med 14: 128–140, 1984.

    Article  CAS  Google Scholar 

  31. Kuweit T, Ganslandt T, Jansen P, et al. Influence of size of regions of interest on PET evaluation of caudate glucose consumption.J Comput Assist Tomogr 16: 789–794, 1992.

    Article  Google Scholar 

  32. Akashi Y, Kuwabara Y, Ichiya Y, Sasaki M, Yoshida T, Fukumura T, et al. The partial volume effect correction for pulmonary mass lesions using a68Ga/68Ge transmission scan in PET study.KAKU IGAKU (Jpn J Nucl Med) 31: 1511–1517, 1994 (in Japanese).

    CAS  Google Scholar 

  33. Minn H, Paul R, Ahonen A. Evaluation of treatment response to radiotherapy in head and neck cancer with Fluorine-18 fluorodeoxyglucose.J Nucl Med 29: 1521–1525, 1988

    PubMed  CAS  Google Scholar 

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Ichiya, Y., Kuwabara, Y., Sasaki, M. et al. FDG-PET in infectious lesions: The detection and assessment of lesion activity. Ann Nucl Med 10, 185–191 (1996). https://doi.org/10.1007/BF03165391

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  • DOI: https://doi.org/10.1007/BF03165391

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