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Comparison of18F-fluoromethylcholine and 2-deoxy-D-glucose in the distribution of tumor and inflammation

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Abstract

Purpose

The distribution characteristics of18F-fluoromethylcholine (18F-choline) in tumor and inflammatory tissue were compared with those of14C or3H-2-deoxyglucose (2DG) as a substitute for fluorodeoxyglucose (FDG).

Methods

A solid tumor model of AH109A in the back of Donryu rats and an aseptic inflammation model of turpentine oil injection subcutaneously in rats were used for experiments. Tissue distribution was examined at 5, 30 and 60 min after injection of a mixture of18F-choline and3H-2DG. Double-tracer high-resolution autoradiographs (ARGs) of tumor and inflammation were obtained using18F-choline and14C-2DG. Whole body (WB) ARG was performed with18F-choline.

Results

Tumor uptake of18F-choline reached a peak at 30 min, when the tumor to blood ratio was 5.1. Both tumor and inflammation uptake of 2DG were higher than those of18F-choline.18F-choline uptake by inflammation was lower than that by tumor. The tumor to brain uptake ratio was 5.7 with18F-choline and 1.2 with 2DG. In the ARG of inflammation, linear or ring-like structures of 2DG uptake were observed in the wall of the abscess, but were not identified with18F-choline. Photomicrography showed that the uptake was limited to granulocytes, macrophages and fibroblasts, consistent with sub-acute or chronic inflammation.

Conclusion

18F-choline uptake by inflammation was lower than that of 2DG in the tissue distribution study, and18F-choline uptake by abscess wall was significantly lower than that of 2DG in the autoradiography study. Our results may suggest the feasibility of18F-choline-PET imaging for the differential diagnosis of cancer and chronic inflammation in lung and brain.

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Correspondence to Kazuo Kubota.

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Kubota, K., Furumoto, S., Iwata, R. et al. Comparison of18F-fluoromethylcholine and 2-deoxy-D-glucose in the distribution of tumor and inflammation. Ann Nucl Med 20, 527–533 (2006). https://doi.org/10.1007/BF03026816

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  • DOI: https://doi.org/10.1007/BF03026816

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