Studies included | Patients | Fatal recurrent VTE | Recurrent VTE | Pooled case-fatality rate % (95% CI) | I2 % | Pooled rate of recurrent fatal VTE per 100 patient-years (95% CI) | Pooled rate of recurrent VTE per 100 patient-years (95% CI) | |
VTE at baseline in studies with low or moderate risk of bias | ||||||||
Unprovoked VTE | 18 | 6758 | 58 | 1079 | 2.6 (0.86–5.0) | 66.60 | 0.17 (0.047–0.33) | 6.3 (5.42–7.3) |
Unprovoked DVT | 13 | 3675 | 45 | 669 | 2.7 (0.50–6.1) | 63.52 | 0.18 (0.025–0.43) | 6.2 (4.6–8.0) |
Unprovoked PE | 9 | 1783 | 8 | 243 | 1.6 (0–5.7) | 48.43 | 0.060 (0–0.28) | 5.6 (4.2–7.1) |
Other subgroups | ||||||||
Overall VTE | 24 | 8914 | 64 | 1545 | 2.0 (0.69–3.8) | 65.21 | 0.13 (0.036–0.25) | 6.2 (5.4–7.2) |
Overall DVT | 17 | 4544 | 49 | 887 | 2.3 (0.52–4.8) | 60.39 | 0.14 (0.022–0.33) | 6.3 (5.0–7.6) |
Overall PE | 13 | 2730 | 9 | 426 | 0.12 (0–1.8) | 34.90 | 0.011 (0–0.11) | 4.9 (4.2–5.7) |
Enrolment before 2000 | 11 | 4245 | 55 | 883 | 4.0 (1.3–7.8) | 76.46 | 0.27 (0.038–0.59) | 6.8 (5.4–8.4) |
Enrolment after January 1, 2000 | 12 | 4508 | 9 | 642 | 0.71 (0.063–1.8) | 0 | 0.039 (0.0028–0.1) | 5.9 (0.47–7.2) |
Cohort | 16 | 6020 | 51 | 1161 | 1.7 (0.19–4.2) | 74.62 | 0.11 (0.009–0.29) | 6.4 (5.3–7.6) |
RCT | 9 | 2894 | 13 | 384 | 2.5 (0.69–5.0) | 26.83 | 0.14 (0.021–0.33) | 6.0 (4.6–7.6) |
Follow-up ≤2.5 years | 12 | 5183 | 16 | 574 | 1.8 (0.46–3.8) | 34.85 | 0.11 (0.018–0.27) | 6.7 (5.2–8.3) |
Follow-up >2.5 years | 12 | 3731 | 48 | 971 | 2.2 (0.22–5.4) | 76.57 | 0.13 (0.076–0.35) | 5.8 (4.8–7.0) |
Data are presented as n, unless otherwise stated. DVT: deep vein thrombosis; PE: pulmonary embolism; RCT: randomised controlled trial.