Pathophysiological changes | Possible adverse clinical effects | |
Elevated pressure | ||
Oxygen | Hyperoxia | Oxidative stress Airway inflammation |
Nitrogen | Venous gas microbubbles | Impaired diffusion capacity Pulmonary hypertension |
Immersion | Central blood pooling Reduced lung compliance Increased work of breathing | Dyspnoea |
Scuba | ||
Breathing gas | Dry and cold gas Increased density of gas Increased airway resistance | Respiratory heat loss Airway inflammation Airway narrowing Dyspnoea |
Pressure regulator | Increased work of breathing | Dyspnoea Aggravation of airway drying and cooling when bypassing nasal airways# |
Exertion | Increased work of breathing | Dyspnoea Carbon dioxide retention Exercise-induced bronchoconstriction Capillary stress failure Pulmonary oedema |
Water | Increased heat conduction and convection Increased respiratory heat loss | Cold stress Hypothermia Hypopnoea Apnoea |
#: when diving using a mask and breathing through a regulator.