Immune system disturbances in Down syndrome
| Mild-to-moderate reduction in T-cell counts Mild-to-moderate reduction in B-cell counts Absence of normal lymphocyte expansion in infancy Thymus size is smaller than age-matched controls Mild-to-moderate reduction in naive T-cell percentages, with corresponding reduction of T-cell excision circles Suboptimal antibody responses to immunisations Decreased total and specific immunoglobulin A in saliva Decreased neutrophil chemotaxis |