Risk factors associated with recurrent venous thromboembolism (VTE) and anticoagulant-related bleeding [2, 12, 46, 50–53]
| Recurrent VTE | Serious or fatal bleeding | Both recurrent VTE and serious bleeding |
| Initial unprovoked VTE | Low platelet count | Increased age |
| Initial proximal DVT or PE | Previous bleeding | Cancer |
| Thrombophilia | Recent major bleeding | Immobilisation |
| Residual proximal thrombosis | Previous stroke | Recent surgery (transient) |
| Male sex | Hepatic failure | Severe renal impairment |
| Elevated D-dimer concentrations when not receiving anticoagulation Pregnancy Anticoagulation lasting<3 months | Diabetes Abnormal prothrombin time Thrombocytopenia Poor anticoagulant control Comorbidity Anaemia |
DVT: deep vein thrombosis; PE: pulmonary embolism.