Adverse events reported in randomised controlled trials (RCTs) after administration of N-acetylcysteine (NAC) at low and high doses
| NAC dose | ||
| Low | High | |
| RCTs | 8 | 3 |
| Gastrointestinal disorders | ||
| Diarrhoea | 5 | 2 |
| Gastrointestinal pain | 4 | 1 |
| Epigastric discomfort | 3 | 1 |
| Nausea | 3 | 0 |
| Vomiting | 3 | 0 |
| Constipation | 2 | 0 |
| Loss of appetite | 1 | 0 |
| Indigestion | 1 | 0 |
| GORD symptoms | 0 | 1 |
| Dry mouth | 0 | 1 |
| Unpleasant taste | 1 | 0 |
| Respiratory disorders | ||
| Dyspnoea | 2 | 0 |
| Respiratory tract infection | 1 | 1 |
| Cough | 1 | 1 |
| Other disorders | ||
| Pyrosis | 3 | 0 |
| Joint pain and muscle pain | 0 | 2 |
| Dizziness | 0 | 2 |
| Palpitations | 0 | 1 |
| Headache | 1 | 1 |
| Skin disorders | 1 | 0 |
| CNS disorders | 1 | 0 |
| Weight gain | 1 | 0 |
| Oedema | 1 | 0 |
| Urticaria | 1 | 0 |
| Itching | 1 | 0 |
| Tinnitus | 1 | 0 |
| Pruritus | 0 | 1 |
Data are presented as n. GORD: Gastro-oesophageal reflux disease; CNS: central nervous system.