Table 3. Respiratory side-effects during bronchial thermoplasty treatments in severe asthma

Study group	Asthma severity	Subjects	Bronchoscopies	Symptoms^#	Symptoms^#per bronchoscopy	Mild %	Moderate %	Severe %	Hospital admissions^¶ (subjects)	Hospital admissions^¶ per bronchoscopy
Feasibility study	Mild to moderate	16	49	155	3.2	84	16	0	0	0
AIR	Moderate to severe	55	161	407	2.5	69	28	3	6 (4)	0.04
AIR2: thermoplasty group	Moderate to severe	190	558	573	1.0	44	53	3.1	19 (16)	0.034
AIR2: sham group	Moderate to severe	98	292	206	0.7	55	40	1.5	2 (2)	0.007
RISA	Severe	15	45	136	3.0	49	41	10	7 (4)	0.156

Data are presented as n, unless otherwise stated. AIR: Asthma Intervention Research; RISA: Research in Severe Asthma. ^#: respiratory-related adverse events during the treatment period (from first bronchoscopy to 6 weeks after the final bronchoscopy); ^¶: during the treatment period.