Proposed criteria for myositis associated with anti-tRNA synthetase antibody
| Features the patient must have |
| Positive serological tests for an anti-tRNA synthetase antibody |
| Plus one major involvement: |
| Evidence of overt or hypomyopathic myositis (elevated CPK levels, myalgia, proximal muscular weakness, positive muscular biopsy, electromyographic triad of myositis or MRI muscular oedema) |
| Evidence of ILD according to ATS criteria |
| Evidence of articular involvement (symmetrical inflammatory arthralgia or overt arthritis) |
| Or two minor involvements: |
| Unexplained persistent fever |
| Raynaud's phenomenon |
| Mechanic's hands |
CPK: creatine phosphokinase; MRI: magnetic resonance imaging; ILD: interstitial lung disease; ATS: American Thoracic Society. Reproduced and modified from [51], with permission from the publisher.