TABLE 2

Biological activities of pro-resolving lipid mediators in asthma and allergic disease models

MediatorActionReferences
LipoxinsInhibits airway hyperresponsiveness and pulmonary inflammation[68, 76]
Resolvin E1Reduces airway inflammation; stimulates LXA4 production; and reduces SRS-A[60]
Resolvin D1Inhibits airway hyperresponsiveness and pulmonary inflammation[54]
Protectin D1Protects from lung damage, airway inflammation and airway hyperresponsiveness[77]

  • LXA4: lipoxin A4; SRS-A: slow-reacting substance of anaphylaxis.