Table 6. Growth inhibitory drug effects in cell lines containing KIT mutations identified in thymic carcinomas
MutationExonImatinibSunitinibDasatinibNilotinib
E490K9+++++NENE
Y553N11+++NENENE
W557R11++++++NENE
V559A11++++++NENE
V560del11++++++++++++
L576P11++++++
P577-D579del11NENENENE
H697Y14++++NENE
D820E1700++++
  • NE: not evaluated; 0: half maximal inhibitory concentration (IC50) >1,000 nM, resistance; +: IC50 between 500 and 1,000 nM, low sensitivity; ++: IC50 between 100 and 500 nM, mid-sensitivity; +++: IC50 <100 nM, high-sensitivity.