Table 9. Pattern of asthmatic reaction on specific inhalation challenge (late versus early) and outcome of occupational asthma

First author [ref.]	Main conclusion	SIGN grade	Study type	Exposure/ occupation	Subjects n
Tarlo [11]	No relationship	3	Descriptive study of disease register	Isocyanates	235
Cote [12]	+ (Severity of early and late)	2+	Longitudinal	Plicatic acid (Western red cedar)	48
Valentino [29]	No relationship	2+	Longitudinal	TDI	50
Lemière [35]	No relationship	3	Longitudinal	Various HMW and LMW agents	15
Marabini [40]	+ (Late)	2+	Longitudinal	TDI	40
Mapp [23]	+ (Late)	2-	Longitudinal	TDI	35

SIGN: Scottish Intercollegiate Guidelines Network; TDI: toluene diisocyanate; HMW: high molecular weight; LMW: low molecular weight. +: effect of the pattern of asthmatic reaction on asthma outcome.