| Case 1 | Case 2 | Case 3 | |
| Age years | 67 | 71 | 72 |
| Sex | Male | Female | Female |
| Smoking status | Ex-smoker | Nonsmoker | Ex-smoker |
| Years of rheumatoid arthritis | 34 | 8 | 43 |
| Rheumatoid factor/anti-CCP | Positive/NA | Positive/positive | Positive/positive |
| CZP dose# | NA | 8 | 4 |
| Onset of symptoms¶ | 15 weeks | 16 weeks | 8 weeks |
| Methotrexate | None | Yes | Yes |
| DAS-28 before CZP | 6.34 | 5.9 | 5.6 |
| DAS-28 after CZP | 6.72 | 1.89 | 5.2 |
| HRCT findings | Ground-glass attenuation | Ground-glass attenuation | Ground-glass attenuation |
| Outcome | Died (18 days after admission) | Impaired, home oxygen supply on exertion | Impaired, home oxygen supply on exertion |
CCP: cyclic citrullinated peptide; DAS-28: disease activity score-28 joints; HRCT: high-resolution computed tomography; NA: not answered. #: number of doses given once in a 2-week interval; ¶: time delay between initiation of therapy and onset of symptoms.