Case | Age yrs | Sex | Symptoms | Smoking history | TMN stage | Maximum dimension cm | Location | Site of metastases | Associated tumour type | Rhabdoid cells % | Follow-up status | [Ref.] |
1 | 54 | F | Haemoptysis | Yes | NA | 8.0≥, ≤1.3 | RUL | Lymph node | Large cell carcinoma | 90 | AWD, 6 months | 11 |
2 | 36 | M | Chest pain | NA | NA | 8.0≥, ≤1.3 | LUL | NA | Sarcoma | >10 | AWD, 4 months | 11 |
3 | 47 | M | Haemoptysis | Yes | NA | 8.0≥, ≤1.3 | RLL | NA | Adenocarcinoma | >10 | DOD, 4 months | 11 |
4 | 71 | F | NA | NA | NA | 8.0≥, ≤1.3 | LUL | Lymph node | Adenocarcinoma | 10 | AWD, 2 months | 11 |
5 | 71 | M | NA | NA | NA | 8.0≥, ≤1.3 | RLL | NA | Large cell carcinoma | >10 | ASU, 5 months | 11 |
6 | 25 | F | Bazex’s syndrome | No | NA | 8.0≥, ≤1.3 | LLL | Lung, lymph node | Large cell carcinoma | 10 | NA | 11 |
7 | 74 | M | None | Yes | NA | 3.5 | LLL | NA | NA | Most | ANED, 24 months | 12 |
8 | 68 | M | Cough, haemoptysis | NA | NA | 3 | RML | Lymph node | Adenocarcinoma | >10 | DOD, 6 months | 13 |
9 | 62 | F | Cough, haemoptysis | Yes | NA | 11 | RUL | Present | LCNEC | 25 | DOD, 3 months | 13 |
10 | 40 | M | Cough, chest pain, dyspnoea | Yes | NA | 6 | RUL | NA | Adenocarcinoma | >10 | LFU, 6 months | 13 |
11 | 50 | F | Cough, dyspnoea | Yes | NA | 17 | LLL | Lymph node | LCNEC, small cell carcinoma | 15 | DOD, 6 months | 14 |
12 | 53 | M | Cough, fatigue | Yes | NA | 12 | LUL | NA | LCNEC, small cell carcinoma, SCC | 10 | DOD, 12 months | 14 |
13 | 51 | M | Haemoptysis | Yes | IIIA | 4 | RUL | Lymph node | Adenocarcinoma | 70 | DOD, 36 months | 15 |
14 | 72 | M | Cough | No | IIIA | 5.6 | RUL | Lymph node | Adenocarcinoma | 90 | DOD, 4 months | 15 |
15 | 50 | F | Fatigue | No | IA | 3.0 | RML | NA | Adenocarcinoma | 50 | ASU, 41 months | 15 |
16 | 69 | M | None | NA | IIIA | 4.5 | RLL | None | Poorly differentiated tumour | 18.2 | DOD, 1.5 months | 8 |
17 | 66 | M | Haemoptysis | NA | IIIB | 6.0 | LUL | None | Poorly differentiated tumour | 15.5 | DOD, 0.6 months | 8 |
18 | 82 | M | Cough, chest pain, dyspnoea | Yes | IIIA | 11.0 | LUL | None | Poorly differentiated tumour | 15 | DOD, 1 | 8 |
19 | 47 | F | Cough, haemoptysis | Yes | IIIA | 8.5 | RUL | None | Poorly differentiated tumour | 60 | DOD, 10 months | 8 |
20 | 69 | F | Chest pain | Yes | NA | 2.0 | RUL | Duodenum, skin adrenal gland | Pseudomesotheliomatous adenocarcinoma | NA | Death, other disease; 3 months | 16 |
21 | 59 | M | NA | Yes | NA | 4.5 | RUL | Adrenal gland | Large cell carcinoma | 90 | ANED, 60 months | 17 |
22 | 70 | F | None | NA | IB | 9 | LL | None | Large cell carcinoma | Pure LCCRP | ANED, 8 months | 18 |
23 | 57 | M | Respiratory | Yes | NA | 23.0 | LUL | Not known | Sarcomatoid carcinoma | 25 | LFU, NA | 7 |
24 | 57 | F | Haemoptysis | Yes | I | 4.0 | LUL | Brain, jejunum | Large cell undifferentiated carcinoma | 90 | DOD, 11 months | 7 |
25 | 54 | M | Haemoptysis | Yes | IV | 4.0 | RUL | Liver, bone, lymph, node | Large cell undifferentiated carcinoma | 15 | DOD, 4 months | 7 |
26 | 48 | F | Hoarseness | Yes | IIIB | 5.1 | RUL | Lung, lymph node | Adenocarcinoma | 10 | DOD, 19 months | 7 |
27 | 54 | M | Haemoptysis, GI bleeding | NA | IV | 10 | RUL | Bowel, soft tissue, lymph node | Large cell undifferentiated carcinoma | 90 | DOD, 5 months | 7 |
28 | 70 | M | None | Yes | IV | NA | Left lung | Bone, chest wall | Adenocarcinoma | 90 | DOD, 10 months | 7 |
29 | 61 | M | Haemoptysis | Yes | IIIA | 4.7 | RUL | Bone, lymph node | Sarcomatoid carcinoma | 30 | DOD, 1.5 months | 7 |
30 | 59 | F | Cough | Yes | IV | NA | RML | Brain, bone, lung, lymph node | Adenocarcinoma | 50 | DOD, 3 months | 7 |
31 | 34 | M | Haemoptysis | NA | IV | 2.0 | LLL | Lung | Sarcomatoid carcinoma | 60 | DOD, 3 months | 7 |
32 | 65 | M | None | NA | IV | NA | LLL | Chest wall | Sarcomatoid carcinoma | 75 | LFU, NA | 7 |
33 | 59 | F | Haemoptysis | Yes | IIIA | 3.0 | LLL | Lymph node | Adenocarcinoma | 20 | ANED, 20 months | 7 |
34 | 55 | M | Cough, haemoptysis | Yes | IV | 3.5 | LUL | Liver, spleen | Large cell carcinoma | Pure LCCRP | DOD, 2 months | 19 |
35 | 50 | M | Chest pain | NA | I | 8 | RUL | None | Large cell carcinoma | NGS | ASU, NA | 20 |
36 | 58 | M | Cough, chest pain, dyspnoea | NA | I | 3 | LLL | None | Large cell carcinoma | NGS | ASU, NA | 20 |
37 | 56 | M | Chest pain, weight loss | NA | I | 4 | RLL | None | Large cell carcinoma | NGS | LFU, NA | 20 |
38 | 63 | M | Cough, chest pain, weight loss | NA | I | 4.8 | RUL | None | Large cell carcinoma | NGS | AWD, NA | 20 |
39 | 37 | M | Cough, haemoptysis, back pain | Yes | IIIB | 5 | RUL | Small intestine, lymph node | Large cell carcinoma | NA | DOD, 6 months | 21 |
40 | 73 | F | Rectal bleeding | Yes | IV | NA | NA | Colon | NA | NA | DOD, 4 months | 2 |
41 | 36 | F | Haemoptysis | No | IB | 6 | LUL | Liver, lymph node | Large cell carcinoma | NA | AWD, 62 months | 1 |
42 | 63 | M | Intussusception | Yes | IV | 9.5 | RLL | Small intestine, lymph node | Poorly differentiated tumour | 80 | DOD, 1 months | Present case report |
F: female; M: male; NA: not available; GI: gastrointestinal; RUL: right upper lobe; LUL: left upper lobe; RLL: right lower lobe; LLL: left lower lobe; RML: right middle lobe; LCNEC: large cell neuroendocrine carcinoma; SCC: squamous cell carcinoma; LCCRP: large cell carcinoma of the lung with rhabdoid phenotype; NGS: no evidence of glandular and/or squamous differentiation; AWD: alive with disease; DOD: dead of disease; ASU: alive, status unknown; ANED: alive with no evidence of disease; LFU: lost to follow-up.