Determinants of prognosis | Better prognosis | Worse prognosis |
Clinical evidence of RVF | No | Yes |
Rate of progression of symptoms | Slow | Rapid |
Syncope | No | Yes |
WHO-FC | I, II | IV |
6MWT | Longer (>500 m) | Shorter (<300 m) |
Cardiopulmonary exercise testing | Peak O2 consumption >15 mL·min−1·kg−1 | Peak O2 consumption <12 mL·min−1·kg−1 |
BNP/NT-proBNP plasma levels | Normal or near normal | Very elevated and rising |
Echocardiographic findings | No pericardial effusion | Pericardial effusion |
TAPSE >2.0 cm | TAPSE <1.5 cm | |
Haemodynamics | Pra <8 mmHg and CI ≥2.5 L·min−1·m−2 | Pra >15 mmHg or CI ≤2.0 L·min−1·m−2 |
RVF: right ventricle failure; WHO-FC: World Health Organization functional class; 6MWT: 6-min walk test; BNP: brain natriuretic peptide; NT-proBNP: N-terminal pro-BNP; TAPSE: tricuspid annular plane systolic excursion; Pra: right atrial pressure; CI: cardiac index. Reproduced from [2] with permission from the publisher.