GRADE recommendations | Strength of recommendation | Level of evidence |
Exposure elimination is the strongest preventive approach to reduce the disease burden of occupational asthma and is the preferred primary prevention approach | Strong | High |
If elimination is not possible, reduction is the second-best option for primary prevention for occupational asthma based on exposure–response relationships | Strong | Moderate |
The evidence for the effectiveness of respirators in preventing occupational asthma is limited and other options higher in the hierarchy of controls for occupational exposures, notably eliminating or minimising exposures at the source or in the environment, should be used preferentially | Strong | Moderate |
Do not use powdered allergen-rich natural rubber latex gloves | Strong | High |
Minimise skin exposure to asthma-inducing agents | Strong | Low |
The strength and clinical relevance of the recommendation was classified according to the system of the Grading of Recommendations Assessment, Development and Evaluation (GRADE) working group [96].