Table 7. Recommendations according to the Grading of Recommendations Assessment, Development and Evaluation (GRADE) working group
GRADE recommendationsStrength of recommendationLevel of evidence
Exposure elimination is the strongest preventive approach to reduce the disease burden of occupational asthma and is the preferred primary prevention approachStrongHigh
If elimination is not possible, reduction is the second-best option for primary prevention for occupational asthma based on exposure–response relationshipsStrongModerate
The evidence for the effectiveness of respirators in preventing occupational asthma is limited and other options higher in the hierarchy of controls for occupational exposures, notably eliminating or minimising exposures at the source or in the environment, should be used preferentiallyStrongModerate
Do not use powdered allergen-rich natural rubber latex glovesStrongHigh
Minimise skin exposure to asthma-inducing agentsStrongLow
  • The strength and clinical relevance of the recommendation was classified according to the system of the Grading of Recommendations Assessment, Development and Evaluation (GRADE) working group [96].