At baseline (prior to therapy) | Every 3–6 months# | 3–6 months after initiation or changes in therapy | In case of clinical worsening | |
Clinical assessment WHO FC/ECG | X | X | X | X |
6MWT¶ | X | X | X | X |
Cardiopulmonary exercise testing¶ | X | X | X | |
BNP/NT-proBNP | X | X | X | X |
Echocardiography | X | X | X | |
RHC | X+ | X§ | X§ |
WHO-FC: World Health Organization functional class; X: assessment is suggested; 6MWT: 6-min walk test; BNP: brain natriuretic peptide; NT-proBNP: N-terminal proBNP; RHC: right heart catheterisation. #: intervals should to be adjusted to individual patients needs; ¶: usually one of the two exercise tests is performed; +: is recommended (table 20⇑); §: should be performed (table 20⇑). Reproduced from 1 with permission from the publisher.