Structural and functional differences of ELR-positive CXC chemokines in the regulation of vascular remodelling
| Chemokine | Effect on angiogenesis | Relevant structural motif | Receptor through which effects on angiogenesis are mediated |
| CXCL1 | Angiogenic | A-T-E-L-R-C-Q-C | CXCR2 |
| CXCL2 | Angiogenic | A-T-E-L-R-C-Q-C | CXCR2 |
| CXCL3 | Angiogenic | V-T-E-L-R-C-Q-C | CXCR2 |
| CXCL5 | Angiogenic | L-R-E-L-R-C-V-C | CXCR2 |
| CXCL8 | Angiogenic | A-K-E-L-R-C-Q-C | CXCR2 |
ELR motif: a conserved amino acid sequence of Glu-Leu-Arg in the amino terminus of CXC chemokines. Reproduced from [11] with permission from the publisher.